Mast Cell-IgE-and Mast Cell-Structural Cell Interactions in Allergic Airway Disease

Title: Mast Cell-IgE-and Mast Cell-Structural Cell Interactions in Allergic Airway Disease

Volume: 2 Issue: 4

Author(s): Ruby Pawankar, Shigeo Yamagishi, Ryuta Takizawa and Toshiaki Yagi

Affiliation:

Keywords: allergy, mast cell, local Ige synthesis, integrins, epithelial cells

Abstract: Allergic diseases like atopic rhinitis, bronchial asthma, and urticaria are prevalent and on the rise. Mast cells are known to play a central role in the immediate phase reaction of allergic diseases through the IgE-mediated release of a variety of chemical mediators like histamine, leukotrienes, and prostaglandins. On the other hand, T lymphocytes, basophils and eosinophils are thought to be responsible in inducing the late phase response. Yet, recent studies show that the mast cell cannot be simplistically assigned a role in the immediate phase allergic response, and that this cell plays a crucial role in ongoing allergic inflammation, including the development of hyper-responsiveness. In the present article, the author will try to discuss the integrated roles of mast cells in IgEmediated allergic inflammation with specific emphasis on the roles of mast cell-IgE networking and mast cellstructural cell interactions in the late phase allergic response and chronic allergic inflammation.

Cite this article as:

Pawankar Ruby, Yamagishi Shigeo, Takizawa Ryuta and Yagi Toshiaki, Mast Cell-IgE-and Mast Cell-Structural Cell Interactions in Allergic Airway Disease, Current Drug Targets - Inflammation & Allergy 2003; 2 (4) . https://dx.doi.org/10.2174/1568010033484016