Abstract
DC-SIGN is a calcium dependent lectin that binds to HIV envelope, gp120, with high affinity. Its expression on dendritic cells, coupled with its ability to facilitate the binding and subsequent transfer of virions to permissive T-cells, has led to the hypothesis that DC-SIGN may serve as a conduit the transfer of HIV from the peripheral mucosa to secondary lymphoid organs. Studies have shown that DC-SIGN bound virions can maintain their infectivity for prolonged periods of time despite evidence that DC-SIGN itself may serve as an antigen receptor. How HIV subverts the normal function of DC-SIGN to establish a primary infection in the host is unclear. Therefore, understanding the structural and immunological basis for DCSIGNs function will help us realize the role that DC-SIGN may play in viral transmission and pathogenesis. Importantly, DC-SIGN / envelope interactions may represent a new target for microbicide and vaccine development efforts. Here, we review recent studies on DC-SIGNs structure and function in an effort to present testable models of DC-SIGNs role in HIV pathogenesis.
Keywords: dc-sign, c-type lectins, dendritic cells, viral attachment, endocytic receptor, hiv transmission
Current HIV Research
Title: Sugar and Spice: Viral Envelope-DC-SIGN Interactions in HIV Pathogenesis
Volume: 1 Issue: 1
Author(s): Stephen V. Su, Kevin B. Gurney and Benhur Lee
Affiliation:
Keywords: dc-sign, c-type lectins, dendritic cells, viral attachment, endocytic receptor, hiv transmission
Abstract: DC-SIGN is a calcium dependent lectin that binds to HIV envelope, gp120, with high affinity. Its expression on dendritic cells, coupled with its ability to facilitate the binding and subsequent transfer of virions to permissive T-cells, has led to the hypothesis that DC-SIGN may serve as a conduit the transfer of HIV from the peripheral mucosa to secondary lymphoid organs. Studies have shown that DC-SIGN bound virions can maintain their infectivity for prolonged periods of time despite evidence that DC-SIGN itself may serve as an antigen receptor. How HIV subverts the normal function of DC-SIGN to establish a primary infection in the host is unclear. Therefore, understanding the structural and immunological basis for DCSIGNs function will help us realize the role that DC-SIGN may play in viral transmission and pathogenesis. Importantly, DC-SIGN / envelope interactions may represent a new target for microbicide and vaccine development efforts. Here, we review recent studies on DC-SIGNs structure and function in an effort to present testable models of DC-SIGNs role in HIV pathogenesis.
Export Options
About this article
Cite this article as:
Su V. Stephen, Gurney B. Kevin and Lee Benhur, Sugar and Spice: Viral Envelope-DC-SIGN Interactions in HIV Pathogenesis, Current HIV Research 2003; 1 (1) . https://dx.doi.org/10.2174/1570162033352129
DOI https://dx.doi.org/10.2174/1570162033352129 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
Call for Papers in Thematic Issues
Management of HIV: Management of HIV: old challenges and new needs
The aim of this thematic issue is to provide the most recent updates regarding the effective management of HIV infection. Antiretroviral therapy (ART) has significantly decreased HIV-related mortality, leading to an enhancement in the quality of life and life expectancy for people living with HIV (PLWH). Despite the numerous advancements ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Design, Synthesis and Biological Evaluation of a Novel Series of Thiadiazole- Based Anticancer Agents as Potent Angiogenesis Inhibitors
Anti-Cancer Agents in Medicinal Chemistry Role of Signaling Pathways in Mesenchymal Stem Cell Differentiation
Current Stem Cell Research & Therapy Current Applications of Artificial Neural Networks in Biochemistry with Emphasis on Cancer Research
Current Biochemical Engineering (Discontinued) Nanomedicines as Cancer Therapeutics: Current Status
Current Cancer Drug Targets Engineering Antibodies for Therapy
Current Pharmaceutical Biotechnology Antimicrobial Sulfated Glycans: Structure and Function
Current Topics in Medicinal Chemistry Cardiovascular-Active Venom Toxins: An Overview
Current Medicinal Chemistry Neuroprotective Effects of Ellagitannins: A Brief Review
Current Drug Targets Brain Injury Associated with Widely Abused Amphetamines: Neuroinflammation, Neurogenesis and Blood-Brain Barrier
Current Drug Abuse Reviews Cyclin-dependent kinase Inhibitors Inspired by Roscovitine: Purine Bioisosteres
Current Pharmaceutical Design Cancer Cell Permeability-Glycoprotein as a Target of MDR Reverters: Possible Role of Novel Dihydropyridine Derivatives
Current Drug Targets Flavonoids in Human Health: From Structure to Biological Activity
Current Nutrition & Food Science Multidimensional Ophthalmic Nanosystems for Molecular Detection and Therapy of Eye Disorders
Current Pharmaceutical Design The Role of β2-Adrenergic Receptors in Inflammation and Allergy
Current Drug Targets - Inflammation & Allergy The Interactions of the 5-HT3 Receptor with Quipazine-Like Arylpiperazine Ligands. The Journey Track at the End of the First Decade of the Third Millennium
Current Topics in Medicinal Chemistry Potential Therapeutic Drugs and Methods for the Treatment of Amyotrophic Lateral Sclerosis
Current Medicinal Chemistry Beneficial and Detrimental Effects of Antioxidants Use in Sports: How is it Balanced?
Current Nutraceuticals Skeletal Muscle in Cancer Cachexia: The Ideal Target of Drug Therapy
Current Cancer Drug Targets Identification and Induction of Cytochrome P450s Involved in the Metabolism of Flavone-8-Acetic Acid in Mice
Drug Metabolism Letters Synthesis and Biological Evaluation of Pyrido(2,3-<i>d</i>)pyrimidines
Mini-Reviews in Organic Chemistry