Abstract
Oxazolomycin, first isolated in 1985, is a novel bioactive compound, exhibiting potent antiviral, antibacterial and cytotoxic activity, and is now known to be the parent of a wider class of compounds. The broad-spectrum activity of oxazolomycin has been attributed to its protonophoric properties. This review outlines the isolation, structural determination, biosynthesis, bioactivity, biological mode of action and synthesis of all members of this compound class. Significantly, the oxazolomycins appear to offer not only a completely novel chemotype as a bioactive lead structure, but also a chemotype, which also exhibits an unusual biological mode of action.
Keywords: Oxazolomycins, chemotype, protonophoric
Current Drug Discovery Technologies
Title: The Oxazolomycins: A Structurally Novel Class of Bioactive Compounds
Volume: 1 Issue: 3
Author(s): Mark G. Moloney, Paul C. Trippier, Muhammad Yaqoob and Zhaoyang Wang
Affiliation:
Keywords: Oxazolomycins, chemotype, protonophoric
Abstract: Oxazolomycin, first isolated in 1985, is a novel bioactive compound, exhibiting potent antiviral, antibacterial and cytotoxic activity, and is now known to be the parent of a wider class of compounds. The broad-spectrum activity of oxazolomycin has been attributed to its protonophoric properties. This review outlines the isolation, structural determination, biosynthesis, bioactivity, biological mode of action and synthesis of all members of this compound class. Significantly, the oxazolomycins appear to offer not only a completely novel chemotype as a bioactive lead structure, but also a chemotype, which also exhibits an unusual biological mode of action.
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Cite this article as:
Moloney G. Mark, Trippier C. Paul, Yaqoob Muhammad and Wang Zhaoyang, The Oxazolomycins: A Structurally Novel Class of Bioactive Compounds, Current Drug Discovery Technologies 2004; 1 (3) . https://dx.doi.org/10.2174/1570163043334974
DOI https://dx.doi.org/10.2174/1570163043334974 |
Print ISSN 1570-1638 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6220 |
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