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Current Drug Targets - Cardiovascular & Hematological Disorders

Editor-in-Chief

ISSN (Print): 1568-0061
ISSN (Online): 1568-0061

Antioxidants in Peripheral Arterial Disease

Author(s): F. Violi, L. Loffredo and A. Marcoccia

Volume 4, Issue 3, 2004

Page: [289 - 294] Pages: 6

DOI: 10.2174/1568006043336212

Price: $65

Abstract

Peripheral arterial disease (PAD) is an important manifestation of systemic atherosclerosis that is characterized by obstruction of the arteries in the lower limbs. Experimental and epidemiological studies suggest a key role for oxidative stress in initiation and progression of the atherosclerotic process. The results of these studies provided a good basis for interventional trials with antioxidants, particularly with vitamin E, but the findings were conflicting. In this paper we review the observational and interventional studies with antioxidants, and ask whether vitamin supplementation should be recommended for PAD patients.

Keywords: peripheral arterial disease, oxidative stress, antioxidants, atherosclerosis


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