Abstract
Despite the advanced and increasing understanding of the pathophysiology of asthma and other allergic diseases, current treatment remains unspecific and targets late events within the allergic cascade. Therefore, a novel and promising approach to treat allergic asthma is antagonizing IgE by anti-IgE antibodies. This review analyzes the role of IgE for the pathology of asthma, summarize the current data about action, safety and efficacy of anti-IgE therapy, and tries to give a rational approach for future indications and directions of treatment with anti-IgE antibodies.
Keywords: asthma, atopy, allergic rhinitis, anti-Ige, monoclonal antibody, treatment
Current Drug Targets - Inflammation & Allergy
Title: Anti-IgE Therapy in Allergic Asthma
Volume: 4 Issue: 5
Author(s): Claudia Rolinck-Werninghaus, Ulrich Wahn and Eckard Hamelmann
Affiliation:
Keywords: asthma, atopy, allergic rhinitis, anti-Ige, monoclonal antibody, treatment
Abstract: Despite the advanced and increasing understanding of the pathophysiology of asthma and other allergic diseases, current treatment remains unspecific and targets late events within the allergic cascade. Therefore, a novel and promising approach to treat allergic asthma is antagonizing IgE by anti-IgE antibodies. This review analyzes the role of IgE for the pathology of asthma, summarize the current data about action, safety and efficacy of anti-IgE therapy, and tries to give a rational approach for future indications and directions of treatment with anti-IgE antibodies.
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Cite this article as:
Rolinck-Werninghaus Claudia, Wahn Ulrich and Hamelmann Eckard, Anti-IgE Therapy in Allergic Asthma, Current Drug Targets - Inflammation & Allergy 2005; 4 (5) . https://dx.doi.org/10.2174/156801005774322162
DOI https://dx.doi.org/10.2174/156801005774322162 |
Print ISSN 1568-010X |
Publisher Name Bentham Science Publisher |
Online ISSN 1568-010X |
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