Abstract
A main feature of HIV infection is the expression of several proinflammatory cytokines. Proinflammatory cytokines expressed as soluble factors or membrane-bound molecules regulate both HIV replication and T cell apoptosis. Proinflammatory cytokines have key roles in the HIV lifecycle, especially at the level of transcription, favouring the ability of HIV to establish latent reservoirs. In addition, proinflammatory cytokines are involved in both CD4+ T cell and CD8+ T cell apoptosis, resulting in immune suppression. Moreover, several HIV proteins such as Nef, Tat, and Vpr hijack proinflammatory cytokine signaling, further underlining the potential importance of inflammation in HIV pathogenesis. In vivo chronic inflammatory conditions have been correlated to increased levels of viremia and accelerated disease progression. This article raises the possibility that inflammation plays a crucial role in both immune suppression and the formation of viral reservoirs during HIV infection. Understanding the role of inflammation in HIV infection could lead to new therapeutic strategies that could ultimately enhance immune restoration and limit the formation of viral reservoirs in HIV-infected patients.
Keywords: hiv, inflammation, tnf, apoptosis, macrophage
Current HIV Research
Title: HIV and Inflammation
Volume: 3 Issue: 3
Author(s): Anne Zelie Decrion, Isabelle Dichamp, Audrey Varin and Georges Herbein
Affiliation:
Keywords: hiv, inflammation, tnf, apoptosis, macrophage
Abstract: A main feature of HIV infection is the expression of several proinflammatory cytokines. Proinflammatory cytokines expressed as soluble factors or membrane-bound molecules regulate both HIV replication and T cell apoptosis. Proinflammatory cytokines have key roles in the HIV lifecycle, especially at the level of transcription, favouring the ability of HIV to establish latent reservoirs. In addition, proinflammatory cytokines are involved in both CD4+ T cell and CD8+ T cell apoptosis, resulting in immune suppression. Moreover, several HIV proteins such as Nef, Tat, and Vpr hijack proinflammatory cytokine signaling, further underlining the potential importance of inflammation in HIV pathogenesis. In vivo chronic inflammatory conditions have been correlated to increased levels of viremia and accelerated disease progression. This article raises the possibility that inflammation plays a crucial role in both immune suppression and the formation of viral reservoirs during HIV infection. Understanding the role of inflammation in HIV infection could lead to new therapeutic strategies that could ultimately enhance immune restoration and limit the formation of viral reservoirs in HIV-infected patients.
Export Options
About this article
Cite this article as:
Decrion Zelie Anne, Dichamp Isabelle, Varin Audrey and Herbein Georges, HIV and Inflammation, Current HIV Research 2005; 3 (3) . https://dx.doi.org/10.2174/1570162054368057
DOI https://dx.doi.org/10.2174/1570162054368057 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
Call for Papers in Thematic Issues
Management of HIV: Management of HIV: old challenges and new needs
The aim of this thematic issue is to provide the most recent updates regarding the effective management of HIV infection. Antiretroviral therapy (ART) has significantly decreased HIV-related mortality, leading to an enhancement in the quality of life and life expectancy for people living with HIV (PLWH). Despite the numerous advancements ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
OMICS-Derived Targets for Inflammatory Gut Disorders: Opportunities for the Development of Nutrition Related Biomarkers
Endocrine, Metabolic & Immune Disorders - Drug Targets Chronic Granulomatous Disease in Childhood
Current Pediatric Reviews Recombinant Interleukin-12 for Immunotherapy: A Double-Sided Sword
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Discovery and Design of Selective Cyclooxygenase-2 Inhibitors as Non-Ulcerogenic, Anti-Inflammatory Drugs with Potential Utility as Anti-Cancer Agents
Current Drug Targets Molecular Basis for Invertebrate Innate Immune Recognition of (1→3)-β- D-Glucan as A Pathogen-Associated Molecular Pattern
Current Pharmaceutical Design Association between Periodontal Health Status and Cognitive Abilitie s. The Role of Cytokine Profile and Systemic Inflammation
Current Alzheimer Research Valeriana jatamansi Constituent IVHD-valtrate As a Novel Therapeutic Agent to Human Ovarian Cancer: in vitro and in vivo Activities and Mechanisms
Current Cancer Drug Targets Erythropoietin in Stroke Therapy: Friend or Foe
Current Medicinal Chemistry Curcumin Targets p53-Fibrinolytic System in TGF-β1 Mediated Alveolar Epithelial Mesenchymal Transition in Alveolar Epithelial Cells
Endocrine, Metabolic & Immune Disorders - Drug Targets Protein Kinases as Tumor Biomarkers and Therapeutic Targets
Current Pharmaceutical Design Thiazolidine: A Potent Candidate for Central Nervous System Diseases
Central Nervous System Agents in Medicinal Chemistry A Fatal Case of Acute Interstitial Pneumonia (AIP) in a Woman Affected by Glioblastoma
Current Drug Safety Pharmacophore Development and SAR Studies of Imidazoline Receptor Ligands
Mini-Reviews in Medicinal Chemistry Oxidative Stress, Preeclampsia and Cardiovascular Disease
Current Hypertension Reviews Bortezomib: A New Pro-Apoptotic Agent in Cancer Treatment
Current Cancer Drug Targets Nitric Oxide, Malnutrition and Chronic Renal Failure
Cardiovascular & Hematological Agents in Medicinal Chemistry Phytochemicals-based Therapeutics against Alzheimer's Disease: An Update
Current Topics in Medicinal Chemistry Pathophysiological Mechanisms of Stress-Induced Intestina Damage
Current Molecular Medicine Matrix Metalloproteinases as Valid Clinical Target
Current Pharmaceutical Design The Role of Non-coding Genome in Cancer-associated Fibroblasts; Stateof- the-Art and Perspectives in Cancer Targeted Therapy
Current Drug Targets