Generic placeholder image

Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents

Editor-in-Chief

ISSN (Print): 1568-0134
ISSN (Online): 1568-0134

Regulation of GLUT4 Transcription and Gene Expression

Author(s): Ann Louise Olson

Volume 5, Issue 2, 2005

Page: [219 - 225] Pages: 7

DOI: 10.2174/1568013053586414

Price: $65

Abstract

The GLUT4 gene is subject to complex tissue-specific and metabolic regulation that has a profound impact on insulin-mediated glucose disposal. The regulation of this gene is of special clinical interest because insulin-mediated glucose homeostasis is highly sensitive to the levels of GLUT4 protein in muscle and adipose tissue. For this reason, the mechanisms of regulated expression of the GLUT4 gene have been intensively studied over the past decade. Understanding the transcriptional mechanisms that underlie the regulated expression of this highly differentiated gene have been slow to emerge, due to the paucity of suitable model systems available for detailed investigation. The development of transgenic mouse models to understand the mechanisms of transcriptional regulation has greatly enhanced out understanding of this gene. Information gained about the regulation of the GLUT4 gene has provided insight into mechanisms by which complex gene regulation occurs through a small number of cis-acting regulatory elements.

Keywords: glut4, mef2, transcription, diabetes, exercise

« Previous

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy