Abstract
Nitrosative stress and nitration of proteins in airway epithelium maybe responsible for steroid resistance in asthma and steroid ineffectiveness in chronic obstructive pulmonary disease (COPD), supporting the potential role of future therapeutic strategies aimed at regulating NO synthesis in asthma and COPD (for example, combination treatment with NOS inhibitors and corticosteroids). Here, the potential role of NO modulators (NO synthase inhibitors and NO donors) has been reviewed, which if are given on a regular basis may have clinical benefit in asthma and COPD.
Keywords: nitric oxide synthase, nitrotyrosine, exhaled breath condensate, exhaled nitric oxide, s-nitrosylation, l-arginine
Current Drug Targets - Inflammation & Allergy
Title: NOS: Molecular Mechanisms, Clinical Aspects, Therapeutic and Monitoring Approaches
Volume: 4 Issue: 2
Author(s): Sergei A. Kharitonov
Affiliation:
Keywords: nitric oxide synthase, nitrotyrosine, exhaled breath condensate, exhaled nitric oxide, s-nitrosylation, l-arginine
Abstract: Nitrosative stress and nitration of proteins in airway epithelium maybe responsible for steroid resistance in asthma and steroid ineffectiveness in chronic obstructive pulmonary disease (COPD), supporting the potential role of future therapeutic strategies aimed at regulating NO synthesis in asthma and COPD (for example, combination treatment with NOS inhibitors and corticosteroids). Here, the potential role of NO modulators (NO synthase inhibitors and NO donors) has been reviewed, which if are given on a regular basis may have clinical benefit in asthma and COPD.
Export Options
About this article
Cite this article as:
Kharitonov A. Sergei, NOS: Molecular Mechanisms, Clinical Aspects, Therapeutic and Monitoring Approaches, Current Drug Targets - Inflammation & Allergy 2005; 4 (2) . https://dx.doi.org/10.2174/1568010053586282
DOI https://dx.doi.org/10.2174/1568010053586282 |
Print ISSN 1568-010X |
Publisher Name Bentham Science Publisher |
Online ISSN 1568-010X |
Related Articles
-
Patent Selections
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Nitric Oxide and L-Arginine Deficiency in Cystic Fibrosis
Current Pharmaceutical Design Anti-Inflammatory and Anti-Oxidant Activity of a New Class of Phenyl- Pyrazolone Derivatives
Current Drug Discovery Technologies Gauging Reactive Metabolites in Drug-Induced Toxicity
Current Medicinal Chemistry The Role of Autophagy in Subarachnoid Hemorrhage: An Update
Current Neuropharmacology The Discovery and Development of Drug Combinations for the Treatment of Various Diseases from Patent Literature (1980-Present)
Current Topics in Medicinal Chemistry Hypoxia-inducible Factor (HIF) in Hormone Signaling During Health and Disease
Cardiovascular & Hematological Agents in Medicinal Chemistry Molecular and Epigenetic Basis of Extracellular Vesicles Cell Repair Phenotypes in Targeted Organ-specific Regeneration
Current Molecular Medicine Electrochemical Oxidation of Prednisolone at Glassy Carbon Electrode and Its Quantitative Determination in Human Serum and Tablets by Osteryoung Square Wave Voltammetry
Current Analytical Chemistry Enteric Coated Guar Gum Microspheres of Ornidazole for Colonic Delivery
Current Nanoscience Retraction Notice: Emerging Targets for COPD Therapy
Current Drug Targets - Inflammation & Allergy Risk Factors for Hyperemesis Gravidarum
Current Women`s Health Reviews Airway Smooth Muscle Cell as Therapeutic Target of Inflammation
Current Medicinal Chemistry Application of In Vivo Animal Models to Characterize the Pharmacokinetic and Pharmacodynamic Properties of Drug Candidates in Discovery Settings
Combinatorial Chemistry & High Throughput Screening Phytochemicals and Antioxidants: An Evaluation in Understanding the Human Lifeline
Current Nutrition & Food Science Novel Therapeutic Targets for Acute Pancreatitis and Associated Multiple Organ Dysfunction Syndrome
Current Drug Targets - Inflammation & Allergy Inspired Nitric Oxide and Modulation of Oxidative Stress During Cardiac Surgery
Current Drug Safety A Review of <i>Saurauia roxburghii</i> Wall. (Actinidiacaea) as a Traditional Medicinal Plant, Its Phytochemical Study and Therapeutic Potential
Mini-Reviews in Medicinal Chemistry The Diagnosis of Large Airway Pathology and the Role of Rigid Bronchoscopy
Current Respiratory Medicine Reviews Anti-Inflammatory and Anti-Allergy Drugs in Rhinosinusitis
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry