Abstract
Signal transduction through reversible protein phosphorylation plays a central role in cellular physiology in both normal and disease states, and mass spectrometry is well-suited to the task of identifying and cataloging protein phosphorylation sites. Recent advances in sample enrichment strategies, instrumentation, and software availability allow researchers to identify hundreds of phosphorylation sites in a single study. However, to take the next step toward translating these findings into clinical application, the biological relevance of the sites must be validated and clinical assays must be developed to monitor phospho-specific biomarkers.
Keywords: Phosphoproteomics, biomarker discovery, mass spectrometry, Phosflow™
Current Proteomics
Title: Phosphoproteomics: Challenges and Opportunities
Volume: 3 Issue: 4
Author(s): Kimberly A. Lee, Gary D. Means and Scott D. Patterson
Affiliation:
Keywords: Phosphoproteomics, biomarker discovery, mass spectrometry, Phosflow™
Abstract: Signal transduction through reversible protein phosphorylation plays a central role in cellular physiology in both normal and disease states, and mass spectrometry is well-suited to the task of identifying and cataloging protein phosphorylation sites. Recent advances in sample enrichment strategies, instrumentation, and software availability allow researchers to identify hundreds of phosphorylation sites in a single study. However, to take the next step toward translating these findings into clinical application, the biological relevance of the sites must be validated and clinical assays must be developed to monitor phospho-specific biomarkers.
Export Options
About this article
Cite this article as:
Lee A. Kimberly, Means D. Gary and Patterson D. Scott, Phosphoproteomics: Challenges and Opportunities, Current Proteomics 2006; 3 (4) . https://dx.doi.org/10.2174/157016406780655559
DOI https://dx.doi.org/10.2174/157016406780655559 |
Print ISSN 1570-1646 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6247 |
Call for Papers in Thematic Issues
Mass spectrometry data acquisition and analysis for proteomics
The Thematic Issue on "Mass spectrometry data acquisition and analysis for proteomics" aims to explore the latest advancements and challenges in the field of proteomics through the lens of mass spectrometry. Proteomics, the large-scale study of proteins and their functions, plays a crucial role in understanding various biological processes and ...read more
Peptides: State-of-Art and Commercialisation Hurdles
The Editors of the Current Proteomics (CP) journal are highly privileged to welcome scientists to submit their scientific research and review articles to be considered for publication in the upcoming thematic issue. The topics should cover various aspects of peptides in regard to their synthetic methodologies, formulation approaches, pharmacological challenges, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
An Overview of Labeled Porphyrin Molecules in Medical Imaging
Recent Patents and Topics on Imaging (Discontinued) AIDS-Related Kaposis Sarcoma: State of the Art and Therapeutic Strategies
Current HIV Research Current Concepts on the Management of Chordoma
Current Drug Therapy The Current Role of PET/CT in Radiotherapy Planning
Current Radiopharmaceuticals 2-Methoxyestradiol as a Potential Cytostatic Drug in Gliomas?
Anti-Cancer Agents in Medicinal Chemistry KSP Inhibitors as Antimitotic Agents
Current Topics in Medicinal Chemistry Efficacy and Tolerability of Vinorelbine in the Cancer Therapy
Current Drug Safety Nanomedicine: A New Frontier in Cancer Therapeutics
Current Drug Delivery Specialisation of the Tropomyosin Composition of Actin Filaments Provides New Potential Targets for Chemotherapy
Current Cancer Drug Targets Beneficial and Adverse Effects of Molecularly Targeted Therapies for Acute Promyelocytic Leukemia in Central Nervous System
CNS & Neurological Disorders - Drug Targets Using Natural Compounds to Target KRAS Mutated Non-Small Cell Lung Cancer
Current Medicinal Chemistry Protein Kinase CK2 in Human Diseases
Current Medicinal Chemistry The Potency of Refined Mouse Models: Implications for Clinical Trials
Current Cancer Therapy Reviews Targeting Tumors Using Estrogen Receptor Ligand Conjugates
Current Cancer Drug Targets The Design of Drug Candidate Molecules as Selective Inhibitors of Therapeutically Relevant Protein Kinases
Current Medicinal Chemistry Pharmacological Interventions for the Prevention and Treatment of Kidney Injury Induced by Radiotherapy: Molecular Mechanisms and Clinical Perspectives
Current Molecular Pharmacology Cyclin-Dependent Kinase 4/6 (Cdk4/6) Inhibitors: Perspectives in Cancer Therapy and Imaging
Mini-Reviews in Medicinal Chemistry Arylurea Derivatives: A Class of Potential Cancer Targeting Agents
Current Topics in Medicinal Chemistry New Perspectives for Melanoma Immunotherapy: Role of IL-12
Current Molecular Medicine Towards Drug Discovery for Brain Tumours: Interaction of Kinins and Tumours at the Blood Brain Barrier Interface
Recent Patents on CNS Drug Discovery (Discontinued)