Abstract
The majority of antidepressants in current use inhibit the uptake of serotonin and/or norepinephrine. Drugs inhibiting the uptake of serotonin, norepinephrine and dopamine (triple reuptake inhibitors) may offer therapeutic advantages compared to single and/or dual reuptake inhibitors. This review provides a rationale for developing this class of compound and describes the results of preclinical and clinical studies with a family of triple reuptake inhibitors.
Keywords: Antidepressant, dopamine, serotonin, norepinephrine, biogenic, amines, depression
CNS & Neurological Disorders - Drug Targets
Title: Triple Reuptake Inhibitors (“Broad Spectrum” Antidepressants)
Volume: 6 Issue: 2
Author(s): Phil Skolnick and Anthony S. Basile
Affiliation:
Keywords: Antidepressant, dopamine, serotonin, norepinephrine, biogenic, amines, depression
Abstract: The majority of antidepressants in current use inhibit the uptake of serotonin and/or norepinephrine. Drugs inhibiting the uptake of serotonin, norepinephrine and dopamine (triple reuptake inhibitors) may offer therapeutic advantages compared to single and/or dual reuptake inhibitors. This review provides a rationale for developing this class of compound and describes the results of preclinical and clinical studies with a family of triple reuptake inhibitors.
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Cite this article as:
Skolnick Phil and Basile S. Anthony, Triple Reuptake Inhibitors (“Broad Spectrum” Antidepressants), CNS & Neurological Disorders - Drug Targets 2007; 6 (2) . https://dx.doi.org/10.2174/187152707780363285
DOI https://dx.doi.org/10.2174/187152707780363285 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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