Abstract
Tuberculosis caused by Mycobacterium tuberculosis has emerged as the biggest curse of our time causing significant morbidity and mortality. Increasing resistance in mycobacterium to existing drugs calls for exploration of metabolic pathways for finding novel drug targets and also for prioritization of known drug targets. Recent advances in molecular biology, bioinformatics and structural biology coupled with availability of M. tuberculosis genome sequence have provided much needed boost to drug discovery process. This review provides a glimpse of attractive drug targets for development of anti-mycobacterial drug development.
Keywords: Tuberculosis, Mycobacterium tuberculosis, multi-drug resistance, current therapy, novel drug targets, epidemiologists, anti-tubercular, para-aminosalicylic acid, host-pathogen, capreomycin, Mycobacterium, Isoniazid, dehydrogenases, menaquinone
Mini-Reviews in Medicinal Chemistry
Title: Targeting Tuberculosis: A Glimpse of Promising Drug Targets
Volume: 12 Issue: 3
Author(s): N. Arora and A. K. Banerjee
Affiliation:
Keywords: Tuberculosis, Mycobacterium tuberculosis, multi-drug resistance, current therapy, novel drug targets, epidemiologists, anti-tubercular, para-aminosalicylic acid, host-pathogen, capreomycin, Mycobacterium, Isoniazid, dehydrogenases, menaquinone
Abstract: Tuberculosis caused by Mycobacterium tuberculosis has emerged as the biggest curse of our time causing significant morbidity and mortality. Increasing resistance in mycobacterium to existing drugs calls for exploration of metabolic pathways for finding novel drug targets and also for prioritization of known drug targets. Recent advances in molecular biology, bioinformatics and structural biology coupled with availability of M. tuberculosis genome sequence have provided much needed boost to drug discovery process. This review provides a glimpse of attractive drug targets for development of anti-mycobacterial drug development.
Export Options
About this article
Cite this article as:
Arora N. and K. Banerjee A., Targeting Tuberculosis: A Glimpse of Promising Drug Targets, Mini-Reviews in Medicinal Chemistry 2012; 12 (3) . https://dx.doi.org/10.2174/1389557511209030187
DOI https://dx.doi.org/10.2174/1389557511209030187 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
Natural Products in Drug Discovery
Natural products have always been one of the important ways of drug discovery due to their novel skeleton and diverse functional group characteristics. According to statistics, between 1981 and 2019, the FDA approved a total of 1,394 small molecule drugs for marketing, of which 930 marketed drugs originated from the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Fabrication and Characterization of Oral Dissolving Films for Tuberculosis Drug Delivery
Nanoscience & Nanotechnology-Asia Inhibitors of Types I and II Dehydroquinase
Mini-Reviews in Medicinal Chemistry Reverse Vaccinology to Computationally Screen Antigenic Epitopes as Potential Vaccine Candidates from Clostridium botulinum Strain Hall A
Current Bioinformatics Update on Anti-TNF-Alpha Treatment in Rheumatic Diseases
Current Drug Therapy Anomalous Vascular Supply of Bronchial Circulation in Cystic Fibrosis Patients with Massive Hemoptysis
Current Respiratory Medicine Reviews Nanobiotechnological Approaches Against Multidrug Resistant Bacterial Pathogens: An Update
Current Drug Metabolism Targeting Cyclooxygenase and Nitric Oxide Pathway Cross-Talk: A New Signal Transduction Pathway for Developing More Effective Anti- Inflammatory Drugs
Current Signal Transduction Therapy Editorial [ The Reversal of Drug Resistance from Bacteria to Cancer Cells Part - I Guest Editor: Joseph Molnar ]
Current Drug Targets Anti-Inflammatory Therapy in Uveitis
Recent Patents on Inflammation & Allergy Drug Discovery Incidental Extracardiac Findings on Coronary Computed Tomography Angiography: A Pictorial Review of Imaging Findings
Current Medical Imaging Playing with Fire: Manipulation of Macrophage Proinflammatory Signal Transduction by the Intracellular Protozoan Toxoplasma gondii
Current Immunology Reviews (Discontinued) Does the Immune System Regulate Mood to Defend against Infection? Evidence from Studies of Immune Factors, Depression, and Antidepressants
Current Psychiatry Reviews Functions of Antimicrobial Peptides in Vertebrates
Current Protein & Peptide Science Autophagy and Crohns Disease: At the Crossroads of Infection, Inflammation, Immunity, and Cancer
Current Molecular Medicine Expression, Purification and Characterisation of Haemophilus influenzae 3-Isopropylmalate Dehydrogenase (LeuB)
Protein & Peptide Letters Currently Available Methods of Bacterial Cell Detection
Current Immunology Reviews (Discontinued) Rheumatoid Arthritis: An Evolutionary Force in Biologics
Current Pharmaceutical Design LC-MS/MS Assay for Quantification of a Novel Antitubercular Molecule S006-830: Pharmacokinetic and Plasma Protein Binding Studies in Rats
Current Pharmaceutical Analysis Acylhydrazide Schiff Bases: DPPH Radical and Superoxide Anion Scavengers
Medicinal Chemistry Glycoconjugates of Quinolines: Application in Medicinal Chemistry
Mini-Reviews in Medicinal Chemistry