Abstract
There is significant potential for the use of adult mesenchymal stem cells in regenerating musckuloskeletal tissues. The sources of these stem cells discussed in this review are bone marrow, blood, adipose tissue, synovium, periosteum & cartilage. Adult mesenchymal stem cells of bone marrow origin are the cells which are heavily investigated in many studies and have been shown capable of producing a variety of connective tissues especially cartilage and bone. It has recently been suggested that bone marrow derived mesenchymal stem cells originate from microvascular pericytes, and, indeed, many of the tissues from which stem cells have been isolated have good vascularisation and they may give a varied source of cells for future treatments. Clinical trials have shown that these cells are able to be successfully used to regenerate tissues with good clinical outcome. Other sources are showing promise, however, is yet to be brought to the clinical level in humans.
Keywords: Adipose tissue, blood, bone marrow, chondrocytes, mesenchymal stem cells, scaffold, synovium, Musculoskeletal Applications, Adult Mesenchymal Stem Cells, Bone
Current Stem Cell Research & Therapy
Title: Sources of Adult Mesenchymal Stem Cells and their Applicability for Musculoskeletal Applications
Volume: 7 Issue: 2
Author(s): Jagdeep Singh Mohal, Hiteshkumar D. Tailor and Wasim S. Khan
Affiliation:
Keywords: Adipose tissue, blood, bone marrow, chondrocytes, mesenchymal stem cells, scaffold, synovium, Musculoskeletal Applications, Adult Mesenchymal Stem Cells, Bone
Abstract: There is significant potential for the use of adult mesenchymal stem cells in regenerating musckuloskeletal tissues. The sources of these stem cells discussed in this review are bone marrow, blood, adipose tissue, synovium, periosteum & cartilage. Adult mesenchymal stem cells of bone marrow origin are the cells which are heavily investigated in many studies and have been shown capable of producing a variety of connective tissues especially cartilage and bone. It has recently been suggested that bone marrow derived mesenchymal stem cells originate from microvascular pericytes, and, indeed, many of the tissues from which stem cells have been isolated have good vascularisation and they may give a varied source of cells for future treatments. Clinical trials have shown that these cells are able to be successfully used to regenerate tissues with good clinical outcome. Other sources are showing promise, however, is yet to be brought to the clinical level in humans.
Export Options
About this article
Cite this article as:
Singh Mohal Jagdeep, D. Tailor Hiteshkumar and S. Khan Wasim, Sources of Adult Mesenchymal Stem Cells and their Applicability for Musculoskeletal Applications, Current Stem Cell Research & Therapy 2012; 7 (2) . https://dx.doi.org/10.2174/157488812799219027
DOI https://dx.doi.org/10.2174/157488812799219027 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Differential Retinal Protein Expressions During form Deprivation Myopia in Albino Guinea Pigs
Current Proteomics ANTI-infective Therapeutics from the Lepidopteran Model Host Galleria mellonella
Current Pharmaceutical Design Natural Sirtuin Modulators in Drug Discovery: A Review (2010 -2020)
Current Medicinal Chemistry Cardiovascular Magnetic Resonance Imaging clarifies cardiac pathophysiology in early, asymptomatic diffuse systemic sclerosis
Inflammation & Allergy - Drug Targets (Discontinued) New Therapeutic Approaches to Liver Fibrosis: A Practicable Route?
Current Medicinal Chemistry Selective Acetyl- and Butyrylcholinesterase Inhibitors Reduce Amyloid-β Ex Vivo Activation of Peripheral Chemo-cytokines From Alzheimer's Disease Subjects: Exploring the Cholinergic Anti-inflammatory Pathway
Current Alzheimer Research Cancer Stem Cell Markers in Nasopharyngeal Carcinoma and Its Relevance for Therapy
Current Traditional Medicine Epigenetic Regulation of Epithelial to Mesenchymal Transition
Current Cancer Drug Targets The Prostaglandin Agonist Beraprost Aggravates Doxorubicin-mediated Apoptosis by Increasing iNOS Expression in Cardiomyocytes
Current Vascular Pharmacology Drug Targeting Approaches and Use of Drug Delivery Systems in Management of Cancer
Current Pharmaceutical Design Chlorella vulgaris: A Multifunctional Dietary Supplement with Diverse Medicinal Properties
Current Pharmaceutical Design New Perspective on the Dual Functions of Indirubins in Cancer Therapy and Neuroprotection
Anti-Cancer Agents in Medicinal Chemistry Communicating Non-Targeted Effects of Ionizing Radiation to Achieve Adaptive Homeostasis in Tissues
Current Molecular Pharmacology Management of Food-Induced Anaphylaxis: Unsolved Challenges
Current Clinical Pharmacology New Molecular Targets in the Treatment of NSCLC
Current Pharmaceutical Design New Therapeutic Strategies for Coeliac Disease: Tissue Transglutaminase as a Target
Current Medicinal Chemistry Radiolabeled Small Molecule Inhibitors of VEGFR - Recent Advances
Current Pharmaceutical Design Biofabrication of Layered Membrane Systems by Using Human Hepatocytes and Endothelial Cells: A Comparative Study
Current Tissue Engineering (Discontinued) Identification of Molecular Targets Associated with Ethanol Toxicity and Implications in Drug Development
Current Pharmaceutical Design Neurodegenerative Pathways in Alzheimer’s Disease: A Review
Current Neuropharmacology