Abstract
With an objective to evaluate the antibacterial activity of triazine derivatives, a series of 2,4,6-trisubstituted- 1,3,5-triazine were synthesized and characterized by FTIR, 1H-NMR, 13C-NMR, mass spectroscopy and elemental analysis. The minimum inhibitory concentration (MIC) of the compounds that displayed favourable zone of inhibition was determined by broth microdilution method. Derivatives with morpholinyl substituent (4a and 4i) demonstrated good in vitro activities against Gram-positive organisms, whereas two of the compound bearing a diethylamino side chain exhibited moderate (4e) to broad spectrum (4j) activity comparable to streptomycin. The promising activity of the latter maybe attributed to the substitution of electron releasing group at para position of phenyl rings.
Keywords: Antibacterial activity, Cyanuric chloride, 1,3,5-triazine, Morpholine, Minimum inhibitory concentration, Staphylococcus aureus, methicillin-resistant, Antimicrobial resistance, side-effect profile, antimalarial, Bacillus subtilis, antileishmanial, Mycobacterium tuberculosis, chromatography, Electron Impact Mass Spectrometer
Letters in Drug Design & Discovery
Title: Synthesis and In Vitro Antibacterial Screening of some New 2,4,6-Trisubstituted-1,3,5-Triazine Derivatives
Volume: 9 Issue: 3
Author(s): Ravi Bhushan Singh, Nirupam Das, Srabanti Jana and Aparoop Das
Affiliation:
Keywords: Antibacterial activity, Cyanuric chloride, 1,3,5-triazine, Morpholine, Minimum inhibitory concentration, Staphylococcus aureus, methicillin-resistant, Antimicrobial resistance, side-effect profile, antimalarial, Bacillus subtilis, antileishmanial, Mycobacterium tuberculosis, chromatography, Electron Impact Mass Spectrometer
Abstract: With an objective to evaluate the antibacterial activity of triazine derivatives, a series of 2,4,6-trisubstituted- 1,3,5-triazine were synthesized and characterized by FTIR, 1H-NMR, 13C-NMR, mass spectroscopy and elemental analysis. The minimum inhibitory concentration (MIC) of the compounds that displayed favourable zone of inhibition was determined by broth microdilution method. Derivatives with morpholinyl substituent (4a and 4i) demonstrated good in vitro activities against Gram-positive organisms, whereas two of the compound bearing a diethylamino side chain exhibited moderate (4e) to broad spectrum (4j) activity comparable to streptomycin. The promising activity of the latter maybe attributed to the substitution of electron releasing group at para position of phenyl rings.
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Cite this article as:
Bhushan Singh Ravi, Das Nirupam, Jana Srabanti and Das Aparoop, Synthesis and In Vitro Antibacterial Screening of some New 2,4,6-Trisubstituted-1,3,5-Triazine Derivatives, Letters in Drug Design & Discovery 2012; 9 (3) . https://dx.doi.org/10.2174/157018012799129936
DOI https://dx.doi.org/10.2174/157018012799129936 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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