Triphenylphosphine Catalyzed, One-Pot, Multicomponent Synthesis of Spirooxindoles

Title: Triphenylphosphine Catalyzed, One-Pot, Multicomponent Synthesis of Spirooxindoles

Volume: 9 Issue: 2

Author(s): Syed Riyaz, A. Naidu and Pramod K. Dubey

Affiliation:

Keywords: Cyclo addition, multicomponent reaction, spirooxindoles, triphenylphosphine, condensation, ethanol, eco-friendly solvent, acetonitrile, methanol, ethyl acetate

Abstract: Multicomponent reaction involving isatin (1), malononitrile (2), and dimedone (3), in the presence of triphenylphosphine as an efficient catalyst in the eco-friendly solvent ethanol, results in the formation of spirooxindole derivatives 4 i.e 2-Amino-5-oxo-7,7-dimethyl spiro[(4H)-5,6,7,8-tetrahydrochromene-4,3-(3H)-indol]-(10H)-2-onecarbonitrile. The reaction proceeds smoothly under mild conditions and the products are obtained in good to excellent yields. This method is applicable to a variety of isatin derivatives.

Cite this article as:

Riyaz Syed, Naidu A. and K. Dubey Pramod, Triphenylphosphine Catalyzed, One-Pot, Multicomponent Synthesis of Spirooxindoles, Letters in Organic Chemistry 2012; 9 (2) . https://dx.doi.org/10.2174/157017812800221771