Abstract
Paliperidone Palmitate is a long-acting intramuscular atypical antipsychotic drug indicated for the acute maintenance treatment of schizophrenia in adults. Its mechanism of action, like all other atypical agents, is attributed to the antagonism of brain dopamine D2 and serotonin 5-HT2A receptors. The pharmacodynamics, pharmacokinetics, and metabolism of paliperidone palmitate are reviewed. Current studies for clinical efficacy of paliperidone palmitate for both acute and maintenance treatment and adherence in adults with schizophrenia are discussed. Studies for safety and tolerability are also reviewed.
Keywords: Atypical Antipsychotics, Nonadherence, Schizophrenia, Paliperidone Palmitate, Long-acting Injectable, clinical efficacy, olanzapine, ziprasidone, risperidone, quetiapine
Reviews on Recent Clinical Trials
Title: Clinical Pharmacology of Paliperidone Palmitate A Parenteral Long-Acting Formulation for the Treatment of Schizophrenia
Volume: 7 Issue: 1
Author(s): Elizabeth Gilday and Henry A. Nasrallah
Affiliation:
Keywords: Atypical Antipsychotics, Nonadherence, Schizophrenia, Paliperidone Palmitate, Long-acting Injectable, clinical efficacy, olanzapine, ziprasidone, risperidone, quetiapine
Abstract: Paliperidone Palmitate is a long-acting intramuscular atypical antipsychotic drug indicated for the acute maintenance treatment of schizophrenia in adults. Its mechanism of action, like all other atypical agents, is attributed to the antagonism of brain dopamine D2 and serotonin 5-HT2A receptors. The pharmacodynamics, pharmacokinetics, and metabolism of paliperidone palmitate are reviewed. Current studies for clinical efficacy of paliperidone palmitate for both acute and maintenance treatment and adherence in adults with schizophrenia are discussed. Studies for safety and tolerability are also reviewed.
Export Options
About this article
Cite this article as:
Gilday Elizabeth and A. Nasrallah Henry, Clinical Pharmacology of Paliperidone Palmitate A Parenteral Long-Acting Formulation for the Treatment of Schizophrenia, Reviews on Recent Clinical Trials 2012; 7 (1) . https://dx.doi.org/10.2174/157488712799363307
DOI https://dx.doi.org/10.2174/157488712799363307 |
Print ISSN 1574-8871 |
Publisher Name Bentham Science Publisher |
Online ISSN 1876-1038 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Essential Hypertension: Translating Pathophysiology into Pharmacogenomics
Current Pharmacogenomics Polyphenols: A Nutraceutical Approach Against Diseases
Recent Patents on Food, Nutrition & Agriculture Pharmacological Treatment of Hypoxic-Ischemic Reperfusion Injury of the Newborn Brain in the Clinical Setting: What are the Possibilities in the Near Future?
Current Pediatric Reviews QT Alterations in Psychopharmacology: Proven Candidates and Suspects
Current Drug Safety Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models
Current Hypertension Reviews Recent Applications of Doebner, Doebner-von Miller and Knoevenagel-Doebner Reactions in Organic Syntheses
Current Organic Synthesis Therapeutic Macromolecular Iron Chelators
Current Medicinal Chemistry Goal Directed Fluid Therapy
Current Pharmaceutical Design A Comprehensive Systemic Literature Review of Pericardial Decompression Syndrome: Often Unrecognized and Potentially Fatal Syndrome
Current Cardiology Reviews A Review of the Chemical and Pharmacological Aspects of the Genus Marrubium
Current Pharmaceutical Design An Unusual Case of Reversible Empty Sella
Endocrine, Metabolic & Immune Disorders - Drug Targets Drug Withdrawal and Hyperphagia: Lessons from Tobacco and Other Drugs
Current Pharmaceutical Design Effects of PPARγ Ligands on Vascular Tone
Current Molecular Pharmacology Medical Management of the Diabetic Patient with Coronary Artery Disease
Current Pharmaceutical Design A Systematic Approach to Hypertensive Urgencies and Emergencies
Current Hypertension Reviews Atypical Antipsychotic Metabolism and Excretion
Current Drug Metabolism Neuropathic Pain and Lung Delivery of Nanoparticulate Drugs: An Emerging Novel Therapeutic Strategy
CNS & Neurological Disorders - Drug Targets MDR1/P-Glycoprotein (ABCB1) as Target for RNA Interference-Mediated Reversal of Multidrug Resistance
Current Drug Targets Difference in Blood Pressure Measurements Between Arms: Methodological and Clinical Implications
Current Pharmaceutical Design Hypertension in Patients with Severe Aortic Stenosis: Emphasis on Antihypertensive Treatment and the Risk of Syncope
Current Hypertension Reviews