Abstract
The antimycobacterial activity of new 18 7-chloroquinoline derivatives, obtained from 4,7-dichloroquinoline, was evaluated against 15 Mycobacterium spp among standardized and clinical isolates using the MTT susceptibility test to obtain minimum inhibitory concentration values (MIC, μg/mL). The results suggested that 7-chloroquinoline compounds are useful leads for new anti-TB drug development. The most active compounds exhibited moderate activity with 16 μg/mL MIC values for all tested microorganisms.
Keywords: 7-Chloroquinoline derivatives, Synthesis, MDR-TB, Antimycobacterial activity, Tuberculosis (TB), Mycobacterium tuberculosis, human immunodeficiency virus (HIV), rifampin (RMP), isonicotinylhydrazine, INH, Heterocyclic systems, quinine, chloroquine, primaquine, amodiaquine
Letters in Drug Design & Discovery
Title: In Vitro Antimycobacterial Activity of New 7-Chloroquinoline Derivatives
Volume: 9 Issue: 2
Author(s): Juan Bueno, Fernando A. Rojas Ruiz, Santiago Villabona Estupinan and Vladimir V. Kouznetsov
Affiliation:
Keywords: 7-Chloroquinoline derivatives, Synthesis, MDR-TB, Antimycobacterial activity, Tuberculosis (TB), Mycobacterium tuberculosis, human immunodeficiency virus (HIV), rifampin (RMP), isonicotinylhydrazine, INH, Heterocyclic systems, quinine, chloroquine, primaquine, amodiaquine
Abstract: The antimycobacterial activity of new 18 7-chloroquinoline derivatives, obtained from 4,7-dichloroquinoline, was evaluated against 15 Mycobacterium spp among standardized and clinical isolates using the MTT susceptibility test to obtain minimum inhibitory concentration values (MIC, μg/mL). The results suggested that 7-chloroquinoline compounds are useful leads for new anti-TB drug development. The most active compounds exhibited moderate activity with 16 μg/mL MIC values for all tested microorganisms.
Export Options
About this article
Cite this article as:
Bueno Juan, A. Rojas Ruiz Fernando, Villabona Estupinan Santiago and V. Kouznetsov Vladimir, In Vitro Antimycobacterial Activity of New 7-Chloroquinoline Derivatives, Letters in Drug Design & Discovery 2012; 9 (2) . https://dx.doi.org/10.2174/157018012799079761
DOI https://dx.doi.org/10.2174/157018012799079761 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Ultrasonographic Assessment of Cirrhosis and Portal Hypertension
Current Medical Imaging Molecular Players in Tuberculosis Drug Development: Another Break in the Cell Wall
Current Medicinal Chemistry Quality-by-design Enabled Chitosan Nanoparticles for Antitubercular Therapy: Formulation, Statistical Optimization, and <i>In Vitro</i> Characterization
Current Drug Therapy Synthesis and Antioxidant Activity of 1,2,4-Triazole linked Thieno[2,3- d]pyrimidine Derivatives
Letters in Drug Design & Discovery From Nucleic Acids to Drug Discovery: Nucleobases as Emerging Templates for Drug Candidates
Current Medicinal Chemistry Antimycobacterial Evaluation of Pyrazinoic Acid Reversible Derivatives
Current Pharmaceutical Design Patent Selections:
Recent Patents on Inflammation & Allergy Drug Discovery Graphical Abstracts
Letters in Drug Design & Discovery Dendrimers and Dendritic Polymers as Anti-infective Agents: New Antimicrobial Strategies for Therapeutic Drugs
Anti-Infective Agents in Medicinal Chemistry Patent Selections
Recent Patents on Inflammation & Allergy Drug Discovery Developments in Chemical Approaches to Treat Tuberculosis in the Last Decade
Current Medicinal Chemistry The Evil Axis of Obesity, Inflammation and Type-2 Diabetes
Endocrine, Metabolic & Immune Disorders - Drug Targets Editorial: Molecular Scenarios Behind Infectious Diseases
Current Medicinal Chemistry The Application of Optical Technology in Microfluidic Systems
Current Proteomics Ultra-Sensitive Electrochemical Sensor for the Determination of Pyrazinamide
Current Analytical Chemistry Microsphere Technology for Chemotherapy of Mycobacterial Infections
Current Pharmaceutical Design Current Pharmaceutical Aspects of Synthetic Quinoline Derivatives
Mini-Reviews in Medicinal Chemistry Pleiotropic Regulatory Genes as A Tool for <i>Streptomyces</i> Strains Bioprospecting and Improvement
Current Biotechnology Nanoparticles vs Cancer: A Multifuncional Tool
Current Topics in Medicinal Chemistry The First Years of Linezolid Experience in Clinical Practice: A Balance and Future Implications
Anti-Infective Agents in Medicinal Chemistry