One-Pot Three-Component Reaction for Synthesis of Highly Substituted Pyrazolo[1,2-a][1,2,4]triazole Derivatives

Title: One-Pot Three-Component Reaction for Synthesis of Highly Substituted Pyrazolo[1,2-a][1,2,4]triazole Derivatives

Volume: 8 Issue: 10

Author(s): Seyed S. Sajadikhah, Malek T. Maghsoodlou, Nourallah Hazeri and Sayyed M. Habibi-Khorassani

Affiliation:

Keywords: Dialkyl acetylenedicarboxylate, isocyanide, multi-component reaction, pyrazolo[1,2-a][1,2,4]triazole, urazole, anti-inflammatory, anti-microbial, anti-hypoxic, analgesic, antibacterial

Abstract: A straightforward, simple and efficient method is described for the synthesis of pyrazolo[1,2-a][1,2,4]triazole derivates via one-pot three-component reaction between isocyanides, dialkyl acetylenedicarboxylate and 4-phenyl urazole (as a NH-acid) in acetone without using any catalyst at ambient temperature. This method offers several advantages such as high yield of products, easy work-up procedure and mild reaction conditions.

Cite this article as:

S. Sajadikhah Seyed, T. Maghsoodlou Malek, Hazeri Nourallah and M. Habibi-Khorassani Sayyed, One-Pot Three-Component Reaction for Synthesis of Highly Substituted Pyrazolo[1,2-a][1,2,4]triazole Derivatives, Letters in Organic Chemistry 2011; 8 (10) . https://dx.doi.org/10.2174/157017811799304188