Abstract
In the present study, we used a new training paradigm in the intelliCage automatic behavioral assessment system to investigate cognitive functions of the transgenic mice harboring London mutation of the human amyloid precursor protein (APP.V717I). Three groups of animals: 5-, 12- and 18-24-month old were subjected to both Water Maze training and the IntelliCage-based appetitive conditioning. The spatial memory deficit was observed in all three groups of transgenic mice in both behavioral paradigms. However, the APP mice were capable to learn normally when co-housed with the wild-type (WT) littermates, in contrast to clearly impaired learning observed when the transgenic mice were housed alone. Furthermore, in the transgenic mice kept in the Intellicage alone, the cognitive deficit of the young animals was modulated by the circadian rhythm, namely was prominent only during the active phase of the day. The novel approach to study the transgenic mice cognitive abilities presented in this paper offers new insight into cognitive dysfunctions of the Alzheimers disease mouse model.
Keywords: Circadian rhythm, group learning, individual learning, IntelliCage, social behavior, amyloid precursor protein, IntelliCage system, ageing, sensorimotor
Current Alzheimer Research
Title: Cognitive Abilities of Alzheimers Disease Transgenic Mice are Modulated by Social Context and Circadian Rhythm
Volume: 8 Issue: 8
Author(s): Anna Kiryk, Gabriela Mochol, Robert K. Filipkowski, Marcin Wawrzyniak, Victoria Lioudyno, Ewelina Knapska, Tomasz Gorkiewicz, Marcin Balcerzyk, Szymon Leski, Fred Van Leuven, Hans-Peter Lipp, Daniel K. Wojcik and Leszek Kaczmarek
Affiliation:
Keywords: Circadian rhythm, group learning, individual learning, IntelliCage, social behavior, amyloid precursor protein, IntelliCage system, ageing, sensorimotor
Abstract: In the present study, we used a new training paradigm in the intelliCage automatic behavioral assessment system to investigate cognitive functions of the transgenic mice harboring London mutation of the human amyloid precursor protein (APP.V717I). Three groups of animals: 5-, 12- and 18-24-month old were subjected to both Water Maze training and the IntelliCage-based appetitive conditioning. The spatial memory deficit was observed in all three groups of transgenic mice in both behavioral paradigms. However, the APP mice were capable to learn normally when co-housed with the wild-type (WT) littermates, in contrast to clearly impaired learning observed when the transgenic mice were housed alone. Furthermore, in the transgenic mice kept in the Intellicage alone, the cognitive deficit of the young animals was modulated by the circadian rhythm, namely was prominent only during the active phase of the day. The novel approach to study the transgenic mice cognitive abilities presented in this paper offers new insight into cognitive dysfunctions of the Alzheimers disease mouse model.
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Kiryk Anna, Mochol Gabriela, K. Filipkowski Robert, Wawrzyniak Marcin, Lioudyno Victoria, Knapska Ewelina, Gorkiewicz Tomasz, Balcerzyk Marcin, Leski Szymon, Van Leuven Fred, Lipp Hans-Peter, K. Wojcik Daniel and Kaczmarek Leszek, Cognitive Abilities of Alzheimers Disease Transgenic Mice are Modulated by Social Context and Circadian Rhythm, Current Alzheimer Research 2011; 8 (8) . https://dx.doi.org/10.2174/156720511798192745
DOI https://dx.doi.org/10.2174/156720511798192745 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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