Abstract
In the present study, we used a new training paradigm in the intelliCage automatic behavioral assessment system to investigate cognitive functions of the transgenic mice harboring London mutation of the human amyloid precursor protein (APP.V717I). Three groups of animals: 5-, 12- and 18-24-month old were subjected to both Water Maze training and the IntelliCage-based appetitive conditioning. The spatial memory deficit was observed in all three groups of transgenic mice in both behavioral paradigms. However, the APP mice were capable to learn normally when co-housed with the wild-type (WT) littermates, in contrast to clearly impaired learning observed when the transgenic mice were housed alone. Furthermore, in the transgenic mice kept in the Intellicage alone, the cognitive deficit of the young animals was modulated by the circadian rhythm, namely was prominent only during the active phase of the day. The novel approach to study the transgenic mice cognitive abilities presented in this paper offers new insight into cognitive dysfunctions of the Alzheimers disease mouse model.
Keywords: Circadian rhythm, group learning, individual learning, IntelliCage, social behavior, amyloid precursor protein, IntelliCage system, ageing, sensorimotor
Current Alzheimer Research
Title: Cognitive Abilities of Alzheimers Disease Transgenic Mice are Modulated by Social Context and Circadian Rhythm
Volume: 8 Issue: 8
Author(s): Anna Kiryk, Gabriela Mochol, Robert K. Filipkowski, Marcin Wawrzyniak, Victoria Lioudyno, Ewelina Knapska, Tomasz Gorkiewicz, Marcin Balcerzyk, Szymon Leski, Fred Van Leuven, Hans-Peter Lipp, Daniel K. Wojcik and Leszek Kaczmarek
Affiliation:
Keywords: Circadian rhythm, group learning, individual learning, IntelliCage, social behavior, amyloid precursor protein, IntelliCage system, ageing, sensorimotor
Abstract: In the present study, we used a new training paradigm in the intelliCage automatic behavioral assessment system to investigate cognitive functions of the transgenic mice harboring London mutation of the human amyloid precursor protein (APP.V717I). Three groups of animals: 5-, 12- and 18-24-month old were subjected to both Water Maze training and the IntelliCage-based appetitive conditioning. The spatial memory deficit was observed in all three groups of transgenic mice in both behavioral paradigms. However, the APP mice were capable to learn normally when co-housed with the wild-type (WT) littermates, in contrast to clearly impaired learning observed when the transgenic mice were housed alone. Furthermore, in the transgenic mice kept in the Intellicage alone, the cognitive deficit of the young animals was modulated by the circadian rhythm, namely was prominent only during the active phase of the day. The novel approach to study the transgenic mice cognitive abilities presented in this paper offers new insight into cognitive dysfunctions of the Alzheimers disease mouse model.
Export Options
About this article
Cite this article as:
Kiryk Anna, Mochol Gabriela, K. Filipkowski Robert, Wawrzyniak Marcin, Lioudyno Victoria, Knapska Ewelina, Gorkiewicz Tomasz, Balcerzyk Marcin, Leski Szymon, Van Leuven Fred, Lipp Hans-Peter, K. Wojcik Daniel and Kaczmarek Leszek, Cognitive Abilities of Alzheimers Disease Transgenic Mice are Modulated by Social Context and Circadian Rhythm, Current Alzheimer Research 2011; 8 (8) . https://dx.doi.org/10.2174/156720511798192745
DOI https://dx.doi.org/10.2174/156720511798192745 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Meet Our Editorial Board Member
Mini-Reviews in Medicinal Chemistry Oral Administration of L-Serine Increases L- and D-Serine Levels in the Plasma and Brain of Fasted Rats
Letters in Drug Design & Discovery Diazenyl Derivatives as Therapeutic and Diagnostic Agents Acting on Central Nervous System
Central Nervous System Agents in Medicinal Chemistry Inhibition of β-Amyloid Aggregation by Albiflorin, Aloeemodin and Neohesperidin and their Neuroprotective Effect on Primary Hippocampal Cells Against β-Amyloid Induced Toxicity
Current Alzheimer Research Lipid based Nanocapsules: A Multitude of Biomedical Applications
Current Pharmaceutical Biotechnology Meet Our Editor-in-Chief
CNS & Neurological Disorders - Drug Targets GPE and GPE Analogues as Promising Neuroprotective Agents
Mini-Reviews in Medicinal Chemistry Coordination of Ribosomal Protein and Ribosomal RNA Gene Expression in Response to TOR Signaling
Current Genomics Disease-Induced Neuroinflammation and Depression
CNS & Neurological Disorders - Drug Targets Meet Our Editorial Board Member:
Current Alzheimer Research Histone Modifications, Stem Cells and Prostate Cancer
Current Pharmaceutical Design Effect of Brain Derived Neurotrophic Factor (BDNF) Gene Variants on Therapeutic Response and the Risk for Schizophrenia
Current Pharmacogenomics Current Opinion in the Pharmaceutical Management of Irritable and Inflammatory Bowel Diseases: Role of ATP
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Mesenchymal Stem Cells and their Exosomes: Promising Therapeutics for Chronic Pain
Current Stem Cell Research & Therapy Docosahexaenoic Acid and Membrane Lipid Domains
Current Organic Chemistry A Relationship between Endothelial Nitric Oxide Synthetase Gene Variants and Substance Use Disorder
Endocrine, Metabolic & Immune Disorders - Drug Targets β-Synuclein Assembly as a Therapeutic Target of Parkinsons Disease and Related Disorders
Current Pharmaceutical Design Effects of Adding Large Doses of Arachidonic Acid to Docosahexaenoic Acid on Social Impairment in Individuals with Autism Spectrum Disorders
Current Psychopharmacology Editorial (Hot Topic: Monoamine Oxidase as a Target in Medicinal Chemistry and Drug Discovery)
Current Topics in Medicinal Chemistry Editorial [ Monitoring Drugs of Abuse in Wastewater and Air ]
Current Drug Abuse Reviews