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Current Respiratory Medicine Reviews

Editor-in-Chief

ISSN (Print): 1573-398X
ISSN (Online): 1875-6387

Vitamin D and Lung Cancer

Author(s): Helga Rhein

Volume 7, Issue 6, 2011

Page: [440 - 443] Pages: 4

DOI: 10.2174/157339811798072649

Price: $65

Abstract

Lung cancer is one of the most common cancers but treatment has limited success and survival rates remain low. The active metabolite of vitamin D, 1,25-dihydroxyvitamin D, has anti-proliferative and pro-apoptotic actions in lung carcinoma cell lines in vitro. Vitamin D deficiency is associated with poor prognosis in lung cancer, and lung cancer survival varies according to vitamin D receptor genotype. Randomized controlled trials should be performed to determine whether vitamin D supplementation might have a role as an adjunct to conventional treatments for lung cancer.

Keywords: Vitamin D, lung cancer, incidence, mortality, chemotherapy, radiotherapy, NSCLC, anti-angiogenic, pro-apoptotic, vitamin D supplementation


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