Abstract
Protein-Protein Interactions (PPIs) play a very important role in many cellular processes and a variety of experimental approaches have been developed for their identification. These approaches however are partial, timeconsuming and they usually suffer from high error rates. Recently, computational methods have been employed to assist for the prediction producing encouraging results. With this work we offer a critical review of recent computational PPI prediction methods by evaluating their strengths and limitations. Moreover we discuss open problems common to all schemes and try to suggest solutions. Finally we propose future research directions which could potentially more effectively handle some of the restrictions of existing approaches.
Keywords: Protein-Protein interactions, computational methods, machine learning, databases, experimental methods, SVM, random forests, Bayesian Classifiers, Neural Networks
Current Bioinformatics
Title: Computational Approaches for the Prediction of Protein-Protein Interactions: A Survey
Volume: 6 Issue: 4
Author(s): Konstantinos A. Theofilatos, Christos M. Dimitrakopoulos, Athanasios K. Tsakalidis, Spyridon D. Likothanassis, Stergios T. Papadimitriou and Seferina P. Mavroudi
Affiliation:
Keywords: Protein-Protein interactions, computational methods, machine learning, databases, experimental methods, SVM, random forests, Bayesian Classifiers, Neural Networks
Abstract: Protein-Protein Interactions (PPIs) play a very important role in many cellular processes and a variety of experimental approaches have been developed for their identification. These approaches however are partial, timeconsuming and they usually suffer from high error rates. Recently, computational methods have been employed to assist for the prediction producing encouraging results. With this work we offer a critical review of recent computational PPI prediction methods by evaluating their strengths and limitations. Moreover we discuss open problems common to all schemes and try to suggest solutions. Finally we propose future research directions which could potentially more effectively handle some of the restrictions of existing approaches.
Export Options
About this article
Cite this article as:
A. Theofilatos Konstantinos, M. Dimitrakopoulos Christos, K. Tsakalidis Athanasios, D. Likothanassis Spyridon, T. Papadimitriou Stergios and P. Mavroudi Seferina, Computational Approaches for the Prediction of Protein-Protein Interactions: A Survey, Current Bioinformatics 2011; 6 (4) . https://dx.doi.org/10.2174/157489311798072981
DOI https://dx.doi.org/10.2174/157489311798072981 |
Print ISSN 1574-8936 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-392X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
A Practical Approach to Diagnosis and Treatment of Symptomatic Thromboembolic Events in Children with Acute Lymphoblastic Leukemia: Recommendations of the “Coagulation Defects” AIEOP Working Group
Recent Patents on Cardiovascular Drug Discovery Chondromodulin-I and Tenomodulin: The Negative Control of Angiogenesis in Connective Tissue
Current Pharmaceutical Design Myocardial Cellular Damage and Antioxidant Status in Off-Pump Versus On-Pump Coronary Artery Bypass Grafting - A Prospective Study
Vascular Disease Prevention (Discontinued) Redox State, Oxidative Stress, and Molecular Mechanisms of Protective and Toxic Effects of Bilirubin on Cells
Current Pharmaceutical Design Working Towards the Development of Vaccines for the Treatment and Prevention of Early Breast Cancer
Current Cancer Therapy Reviews Cell Responses to Oxidative Stressors
Current Pharmaceutical Design Heme Oxygenase -1 Gene Therapy: Recent Advances and Therapeutic Applications
Current Gene Therapy Substituted Benzimidazole Derivatives as Angiotensin II -AT1 Receptor Antagonist: A Review
Mini-Reviews in Medicinal Chemistry Volatile Disease Biomarkers in Breath: A Critique
Current Pharmaceutical Biotechnology Metabolic Remodeling Induced by Adipocytes: A New Achilles' Heel in Invasive Breast Cancer?
Current Medicinal Chemistry Potential Applications of Hydrogen Sulfide-Induced Suspended Animation
Current Medicinal Chemistry The Evolving Roles of Nuclear Cardiology
Current Cardiology Reviews Validity of Oxygen-Ozone Therapy as Integrated Medication Form in Chronic Inflammatory Diseases
Cardiovascular & Hematological Disorders-Drug Targets Editorial
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Phosphatidylinositol 3-kinase Signaling as a Therapeutic Target for Cervical Cancer
Current Cancer Drug Targets Targeting Adhesion Molecules in Cardiovascular Disorders
Cardiovascular & Hematological Disorders-Drug Targets From the Deepest Sea Shelf to the Uppermost Kitchen Cabinet Shelf: The Quest for Novel TNF-α Inhibitors
Current Topics in Medicinal Chemistry Structure and Dynamics of Cardiotoxins
Current Protein & Peptide Science New Developments in Anthracycline-Induced Cardiotoxicity
Current Medicinal Chemistry Epidemiology and Costs of Hypertension-related Disorders
Current Pharmaceutical Design