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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Solvent-Free Microwave-Assisted Synthesis of Substituted Pyridines Using NH4OAc as Nitrogen Source

Author(s): Jorge Trilleras, Pedro De La Torre, Dency J. Pacheco, Jairo Quiroga, Manuel Nogueras and Justo Cobo

Volume 8, Issue 9, 2011

Page: [652 - 655] Pages: 4

DOI: 10.2174/157017811799304296

Price: $65

Abstract

New 1,5-dicarbonyl compounds were prepared, as versatile precursors to pyridine derivatives, by a tandem Claisen-Schmidt condensation/ Michael addition reaction, that is condensation between 5-chloro-3-methyl-1-phenyl-1Hpyrazole- 4-carbaldehyde and acetophenones, and the formed adduct then reacts with a second molecule of acetophenone. The preparation of substituted pyridines was achieved using NH4OAc as nitrogen source under solvent-free microwave irradiation.

Keywords: Chalcone, 1,5-dicarbonyl compounds, cyclocondensation, microwave, NH4OAc, pyridines, solvent-free procedure, heterocyclic, antifungal, antibacterial


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