Abstract
Regulatory T (Treg) cells play an important role in the maintenance of self-tolerance and are involved in the prevention of autoimmune diseases and reduce/inhibit the progression of chronic inflammatory diseases. Forkhead box P3 (FoxP3) expression in Treg cells is believed to be a critical factor in the maintenance of Treg cells suppressive function. Multiple mechanisms of action of Treg cells have been proposed, including cell contact – dependent and cytokinedependent mechanisms. However, no clear picture is available to fully elucidate the regulation of FoxP3 gene expression in Treg cells and how FoxP3-expressing Treg cells mediate the immune response in vivo. This review will discuss the research advancements in Treg cell biology including the transcription factors and signaling pathways involved in the expression of FoxP3 gene as well as the advancements in the understanding of the factors involved in the Treg cell-mediated suppressive mechanisms.
Keywords: cell differentiation, FoxP3, immune regulation, Regulatory T cells, signal transduction, Activation-induced cell death, Activator protein, Antigen presenting cells, Activating transcription factor, B cell lymphoma/leukemia 10, CARD-containing MAGUK protein 1
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title: The Regulation of FoxP3-Expressing Regulatory T Cells
Volume: 11 Issue: 4
Author(s): Rizwanul Haque, Fengyang Lei, Xiaofang Xiong and Jianxun Song
Affiliation:
Keywords: cell differentiation, FoxP3, immune regulation, Regulatory T cells, signal transduction, Activation-induced cell death, Activator protein, Antigen presenting cells, Activating transcription factor, B cell lymphoma/leukemia 10, CARD-containing MAGUK protein 1
Abstract: Regulatory T (Treg) cells play an important role in the maintenance of self-tolerance and are involved in the prevention of autoimmune diseases and reduce/inhibit the progression of chronic inflammatory diseases. Forkhead box P3 (FoxP3) expression in Treg cells is believed to be a critical factor in the maintenance of Treg cells suppressive function. Multiple mechanisms of action of Treg cells have been proposed, including cell contact – dependent and cytokinedependent mechanisms. However, no clear picture is available to fully elucidate the regulation of FoxP3 gene expression in Treg cells and how FoxP3-expressing Treg cells mediate the immune response in vivo. This review will discuss the research advancements in Treg cell biology including the transcription factors and signaling pathways involved in the expression of FoxP3 gene as well as the advancements in the understanding of the factors involved in the Treg cell-mediated suppressive mechanisms.
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Cite this article as:
Haque Rizwanul, Lei Fengyang, Xiong Xiaofang and Song Jianxun, The Regulation of FoxP3-Expressing Regulatory T Cells, Endocrine, Metabolic & Immune Disorders - Drug Targets 2011; 11 (4) . https://dx.doi.org/10.2174/187153011797881157
DOI https://dx.doi.org/10.2174/187153011797881157 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
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