Abstract
The cellular substrates of sleep are incompletely described, but historically they have been thought to be neuronal. According to one view, sleep is produced by interactions between wake-promoting neurons, sleep-inducing neurons, and sleep-inducing substances released by neurons (e.g. adenosine)[1, 2]. Alternatively, sleep pressure may arise independently among subsets of neurons in a use-dependent fashion within the neocortex (i.e. ‘local’ sleep) [3, 4]. Implicit in both views is the notion that changes in neuronal activity (or plasticity) is the principle mechanism driving sleep homeostasis. Recent findings, however, suggest that the glial cells known as astrocytes may play critical roles in mammalian sleep.
Keywords: Astrocyte, gliotransmission, glia, non-neuronal, mammalian sleep, enzymatic mechanisms, excitatory neurotransmitters, glycogen synthase, cortical glycogen, cerebral glycogen levels, hippocampus of intact rats, brain glycogen content, neuronal signals, Cultured cells, astrocytic influences, neurotransmitter receptors
Current Topics in Medicinal Chemistry
Title: Beyond the Neuron: Astroglial Regulation of Mammalian Sleep
Volume: 11 Issue: 19
Author(s): Marcos G. Frank
Affiliation:
Keywords: Astrocyte, gliotransmission, glia, non-neuronal, mammalian sleep, enzymatic mechanisms, excitatory neurotransmitters, glycogen synthase, cortical glycogen, cerebral glycogen levels, hippocampus of intact rats, brain glycogen content, neuronal signals, Cultured cells, astrocytic influences, neurotransmitter receptors
Abstract: The cellular substrates of sleep are incompletely described, but historically they have been thought to be neuronal. According to one view, sleep is produced by interactions between wake-promoting neurons, sleep-inducing neurons, and sleep-inducing substances released by neurons (e.g. adenosine)[1, 2]. Alternatively, sleep pressure may arise independently among subsets of neurons in a use-dependent fashion within the neocortex (i.e. ‘local’ sleep) [3, 4]. Implicit in both views is the notion that changes in neuronal activity (or plasticity) is the principle mechanism driving sleep homeostasis. Recent findings, however, suggest that the glial cells known as astrocytes may play critical roles in mammalian sleep.
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Cite this article as:
G. Frank Marcos, Beyond the Neuron: Astroglial Regulation of Mammalian Sleep, Current Topics in Medicinal Chemistry 2011; 11 (19) . https://dx.doi.org/10.2174/156802611797470321
DOI https://dx.doi.org/10.2174/156802611797470321 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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