Generic placeholder image

Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and In Vitro Antitumor Activity of Novel Fluorine Containing Pyrazoles and Pyrazolines

Author(s): Ashish Sharma, Tabreskhan Pathan, Rhea Mohan and C. S. Ramaa

Volume 8, Issue 9, 2011

Page: [843 - 849] Pages: 7

DOI: 10.2174/157018011797200812

Price: $65

Abstract

Novel fluorine-containing pyrazolines (2a-2g) and pyrazoles (5a-5e) were synthesized and evaluated for their cytotoxicity in vitro in a panel of four human cancer cell lines using Sulforhodamine B (SRB) assay. Though the compounds showed varying degrees of cytotoxicity in different cell lines, it was noteworthy that the 4H pyrazoles (5a-5e) were distinguished by their potent and selective action against MCF7 breast cancer cell line.

Keywords: Breast cancer cell line, Cytotoxicity, Pyrazoles, Pyrazolines, Sulforhodamine B Assay, antitumor activity, radiotherapy, fluorine, antitubercular, antimalarial, nucleophilic centers, heterocycles, antidepressant, breast cancer, MCF7, vagal nerve


Rights & Permissions Print Export Cite as
© 2024 Bentham Science Publishers | Privacy Policy