Abstract
Three 2-methoxy-4-substituted pyrimidine compounds were chemoselectively synthesized by diazotization, using 2,4-dichloropyrimidine as the starting material. In nonaqueous diazotization reaction system, halo-substituted 6 and 7 were efficiently prepared, and in aqueous medium, hydrolysis product 8 was afforded.
Keywords: 2-methoxy-4-substituted pyrimidine, azaheterocycles, chemoselective synthesis, diazotization, hydrolysis, antibiotics, vitamins, alkaloids, heterocyclic pyrimidines, catalysis
Letters in Organic Chemistry
Title: Highly Efficient, Chemoselective Syntheses of 2-Methoxy-4-substituted Pyrimidines
Volume: 8 Issue: 8
Author(s): Chunyan Xu, Chuanjie Cheng, Hongtao Liu and Bo Liu
Affiliation:
Keywords: 2-methoxy-4-substituted pyrimidine, azaheterocycles, chemoselective synthesis, diazotization, hydrolysis, antibiotics, vitamins, alkaloids, heterocyclic pyrimidines, catalysis
Abstract: Three 2-methoxy-4-substituted pyrimidine compounds were chemoselectively synthesized by diazotization, using 2,4-dichloropyrimidine as the starting material. In nonaqueous diazotization reaction system, halo-substituted 6 and 7 were efficiently prepared, and in aqueous medium, hydrolysis product 8 was afforded.
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Cite this article as:
Xu Chunyan, Cheng Chuanjie, Liu Hongtao and Liu Bo, Highly Efficient, Chemoselective Syntheses of 2-Methoxy-4-substituted Pyrimidines, Letters in Organic Chemistry 2011; 8 (8) . https://dx.doi.org/10.2174/157017811797249371
DOI https://dx.doi.org/10.2174/157017811797249371 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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