Abstract
“How do drugs cross the plasma membrane?” this may seem like a trivial question. This question is often overlooked to focus primarily on the different complex macro-molecular aspects involved in drug delivery or drug resistance. However, recent studies have highlighted the theme that to be fully understood, more knowledge of the underlying biology of the most complex biological processes involved in the delivery and resistance to drugs is needed. After all, why would a drug interact with a transporter then subsequently be excluded from P-glycoprotein (P-gp) expressing drug resistant cells? What are the determinants of this transition in behavior? Full consideration of the physical biology of drug delivery has allowed a better understanding of the reasons why specific membrane proteins are upregulated or overexpressed in drug resistant cells. This, in turn, allows us to identify new targets for drug chemicals. Better yet, it increases the significance of recents patents and underlines their importance in multi drug resistance.
Keywords: Cell membrane, drug delivery, drug resistance, pharmacokinetics, physical biology, antitumor agents, diffusion, hydrophobicity, cytosolic pH
Recent Patents on Anti-Cancer Drug Discovery
Title: Teaching New Dogs Old Tricks: Membrane Biophysical Properties in Drug Delivery and Resistance
Volume: 6 Issue: 3
Author(s): Nina Milosavljevic, Adam Blanchard, Miriam L. Wahl, Salvador Harguindey, Mallorie Poet, Laurent Counillon and Cyril Rauch
Affiliation:
Keywords: Cell membrane, drug delivery, drug resistance, pharmacokinetics, physical biology, antitumor agents, diffusion, hydrophobicity, cytosolic pH
Abstract: “How do drugs cross the plasma membrane?” this may seem like a trivial question. This question is often overlooked to focus primarily on the different complex macro-molecular aspects involved in drug delivery or drug resistance. However, recent studies have highlighted the theme that to be fully understood, more knowledge of the underlying biology of the most complex biological processes involved in the delivery and resistance to drugs is needed. After all, why would a drug interact with a transporter then subsequently be excluded from P-glycoprotein (P-gp) expressing drug resistant cells? What are the determinants of this transition in behavior? Full consideration of the physical biology of drug delivery has allowed a better understanding of the reasons why specific membrane proteins are upregulated or overexpressed in drug resistant cells. This, in turn, allows us to identify new targets for drug chemicals. Better yet, it increases the significance of recents patents and underlines their importance in multi drug resistance.
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Milosavljevic Nina , Blanchard Adam, L. Wahl Miriam, Harguindey Salvador , Poet Mallorie, Counillon Laurent and Rauch Cyril, Teaching New Dogs Old Tricks: Membrane Biophysical Properties in Drug Delivery and Resistance, Recent Patents on Anti-Cancer Drug Discovery 2011; 6 (3) . https://dx.doi.org/10.2174/157489211796957829
DOI https://dx.doi.org/10.2174/157489211796957829 |
Print ISSN 1574-8928 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3970 |
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