Abstract
In regard of increasing rates of post-stroke mood disorders and evidences of a neuroprotective effect of antbiotics after cerebral ischemia we have reviewed the clinical relevance of the neuroprotective and mood stabilizing effects of antibiotics in the light of the basic pathophsiology of depression.
Keywords: Cerebral ischemia, post-stroke mood disorders, neuroprotection, antibiotics, pathophsiology, depression, antidepressant effects, minocycline, mTOR
Mini-Reviews in Medicinal Chemistry
Title: Towards A Multimodal Treatment of Depression: A Minireview on the Potential Role of Antibiotics
Volume: 11 Issue: 11
Author(s): B. Yulug and W.-R. Schabitz
Affiliation:
Keywords: Cerebral ischemia, post-stroke mood disorders, neuroprotection, antibiotics, pathophsiology, depression, antidepressant effects, minocycline, mTOR
Abstract: In regard of increasing rates of post-stroke mood disorders and evidences of a neuroprotective effect of antbiotics after cerebral ischemia we have reviewed the clinical relevance of the neuroprotective and mood stabilizing effects of antibiotics in the light of the basic pathophsiology of depression.
Export Options
About this article
Cite this article as:
Yulug B. and Schabitz W.-R., Towards A Multimodal Treatment of Depression: A Minireview on the Potential Role of Antibiotics, Mini-Reviews in Medicinal Chemistry 2011; 11 (11) . https://dx.doi.org/10.2174/138955711797068418
DOI https://dx.doi.org/10.2174/138955711797068418 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Sigma-1 Receptors and Selective Serotonin Reuptake Inhibitors: Clinical Implications of their Relationship
Central Nervous System Agents in Medicinal Chemistry Recent Advances in the Development of Selective Ligands for the Cannabinoid CB2 Receptor
Current Topics in Medicinal Chemistry Disease-Modifying Agents in the Treatment of Multiple Sclerosis: A Review of Long-Term Outcomes
CNS & Neurological Disorders - Drug Targets Resilience to Alzheimer's Disease: The Role of Physical Activity
Current Alzheimer Research Overview of Molecular Signal Transduction of Malignant Gliomas and Correlation with Responses to Targeted Therapy Recent advances in Molecular Characterization of Glioblastoma
Current Signal Transduction Therapy Recent Patents in CNS Drug Discovery: The Management of Inflammation in the Central Nervous System
Recent Patents on CNS Drug Discovery (Discontinued) Nerve Growth Factor: Early Studies and Recent Clinical Trials
Current Neuropharmacology The Association of Palmitoylethanolamide with Luteolin Decreases Neuroinflammation and Stimulates Autophagy in Parkinson's Disease Model
CNS & Neurological Disorders - Drug Targets Regulation of Multidrug Resistance by Pro-Inflammatory Cytokines
Current Cancer Drug Targets Delivery Systems of Opioid Analgesics for Pain Relief: A Review
Current Pharmaceutical Design Mesenchymal Stem Cell Therapy in Intracerebral Haemorrhagic Stroke
Current Medicinal Chemistry Nanoparticles: A Promising Therapeutic Approach in Atherosclerosis
Current Drug Delivery Sex Steroids in Autoimmune Diseases
Current Topics in Medicinal Chemistry Current and Future Therapeutic Strategies for Parkinsons Disease
Current Pharmaceutical Design Improving Cognitive Outcome in Cerebral Malaria: Insights from Clinical and Experimental Research
Central Nervous System Agents in Medicinal Chemistry Interleukin-1β Plays a Role in the Activation of Peripheral Leukocytes after Blood-Brain Barrier Rupture in the Course of Subarachnoid Hemorrhage
Current Neurovascular Research Pharmacokinetic Mechanisms for Reduced Toxicity of Irinotecan by Coadministered Thalidomide
Current Drug Metabolism Rheumatic Manifestations in Malignancy
Current Rheumatology Reviews TGF-b: A Fibrotic Factor in Wound Scarring and a Potential Target for Anti- Scarring Gene Therapy
Current Gene Therapy Cognitive Impairment with Vascular Impairment and Degeneration
Current Neurovascular Research