Rapid and Efficient Synthesis of New Deoxycholic Acid Thiosemicarbazone Derivatives under Solvent-Free Conditions using Microwaves

Title: Rapid and Efficient Synthesis of New Deoxycholic Acid Thiosemicarbazone Derivatives under Solvent-Free Conditions using Microwaves

Volume: 8 Issue: 7

Author(s): Zhi-Chuan Shi, Zhi-Gang Zhao, Xing-Li Liu and Li-Ying Qiu

Affiliation:

Keywords: Antimicrobial activity, deoxycholic acid, microwave irradiation, solvent-free, steroids, thiosemicarbazone, ESI-Mass, elemental analyses, deoxycholic, antimalarial agents

Abstract: An efficient and simple method for the synthesis of new deoxycholic acid thiosemicarbazone derivatives under solvent-free conditions using microwave irradiation has been developed. Its main advantages are short reaction times, good conversions, highly selective and the environment friendly nature of the process. Their structures were elucidated by IR, 1H NMR, ESI-Mass and elemental analyses. The preliminary results indicate that some of these compounds possess inhibitory effects against Escherichia coli.

Cite this article as:

Shi Zhi-Chuan, Zhao Zhi-Gang, Liu Xing-Li and Qiu Li-Ying, Rapid and Efficient Synthesis of New Deoxycholic Acid Thiosemicarbazone Derivatives under Solvent-Free Conditions using Microwaves, Letters in Organic Chemistry 2011; 8 (7) . https://dx.doi.org/10.2174/157017811796505016