Abstract
Dihydropyrazole, a small bioactive molecule, is a prominent structural motif found in numerous pharmaceutically active compounds. The chiral dihydropyrazole structure has been demonstrated to bear important biological activities such as anticancer, antimicrobial, antimalarial, antinociceptive, antiviral, antitubercular, antiinflammatory, anticonvulsant and steroidal, and can also act as MAO inhibitors, CB1 receptor antagonists and nitric oxide synthase inhibitors. The review describes the latest advances in the synthesis of dihydropyrazole derivatives incorporating physiologically active substances. It is the first attempt at a general and systematic account of the extensive literature data on this subject.
Keywords: Dihydropyrazole, biological activities, SAR, lead, Cannabinoid Receptor 1, Monoamine Oxidase, Structure Activity Relationship, Human Promyelocytic Leukemia, Mouse Lymphoma, Human Prostate Cancer, Human Epidermoid Carcinoma Cancer, T Lymphocytic Leukemia, Human Gastric Cancer, Hman Lukemic Lmphoblasts, Human Myeloma, National Cancer Institute, Epidermal Growth Factor Receptor, Minimum Inhibitory Concentrations, Human Breast Adenocarcinoma, 3-(4,5-Dimethyl-2-Thiazyl)-2,5-Diphenyl-2H-Tetrazolium Bromide, Dimethyl Sulfoxide, Mueller-Hinton, Phosphate Buffered Saline, Enzymelinked Immunosorbentassy, Tlomere Rpeat Aplification Potocol
Mini-Reviews in Medicinal Chemistry
Title: Synthesis and Biological Activity of Chiral Dihydropyrazole: Potential Lead for Drug Design
Volume: 11 Issue: 9
Author(s): X.-H. Liu, B.-F. Ruan, J. Li, F.-H. Chen, B.-A. Song, H.-L. Zhu, P. S. Bhadury and J. Zhao
Affiliation:
Keywords: Dihydropyrazole, biological activities, SAR, lead, Cannabinoid Receptor 1, Monoamine Oxidase, Structure Activity Relationship, Human Promyelocytic Leukemia, Mouse Lymphoma, Human Prostate Cancer, Human Epidermoid Carcinoma Cancer, T Lymphocytic Leukemia, Human Gastric Cancer, Hman Lukemic Lmphoblasts, Human Myeloma, National Cancer Institute, Epidermal Growth Factor Receptor, Minimum Inhibitory Concentrations, Human Breast Adenocarcinoma, 3-(4,5-Dimethyl-2-Thiazyl)-2,5-Diphenyl-2H-Tetrazolium Bromide, Dimethyl Sulfoxide, Mueller-Hinton, Phosphate Buffered Saline, Enzymelinked Immunosorbentassy, Tlomere Rpeat Aplification Potocol
Abstract: Dihydropyrazole, a small bioactive molecule, is a prominent structural motif found in numerous pharmaceutically active compounds. The chiral dihydropyrazole structure has been demonstrated to bear important biological activities such as anticancer, antimicrobial, antimalarial, antinociceptive, antiviral, antitubercular, antiinflammatory, anticonvulsant and steroidal, and can also act as MAO inhibitors, CB1 receptor antagonists and nitric oxide synthase inhibitors. The review describes the latest advances in the synthesis of dihydropyrazole derivatives incorporating physiologically active substances. It is the first attempt at a general and systematic account of the extensive literature data on this subject.
Export Options
About this article
Cite this article as:
Liu X.-H., Ruan B.-F., Li J., Chen F.-H., Song B.-A., Zhu H.-L., S. Bhadury P. and Zhao J., Synthesis and Biological Activity of Chiral Dihydropyrazole: Potential Lead for Drug Design, Mini-Reviews in Medicinal Chemistry 2011; 11 (9) . https://dx.doi.org/10.2174/138955711796355285
DOI https://dx.doi.org/10.2174/138955711796355285 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
Natural Products in Drug Discovery
Natural products have always been one of the important ways of drug discovery due to their novel skeleton and diverse functional group characteristics. According to statistics, between 1981 and 2019, the FDA approved a total of 1,394 small molecule drugs for marketing, of which 930 marketed drugs originated from the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Drug Design For Flavivirus Proteases: What Are We Missing?
Current Pharmaceutical Design Dengue Virus RNA Polymerase NS5: A Potential Therapeutic Target?
Current Drug Targets Pathogenesis of Central Nervous System Tuberculosis
Current Molecular Medicine Initiation of the Immune Response by Extracellular Hsp72: Chaperokine Activity of Hsp72
Current Immunology Reviews (Discontinued) Human Parvovirus B19: An Infectious Agent with the Potential to Induce and Trigger Rheumatic Disease
Current Rheumatology Reviews Molecular Approach to Targeted Therapy for Multiple Sclerosis
CNS & Neurological Disorders - Drug Targets Advancement in Nanoparticle-based Biosensors for Point-of-care <i>In vitro</i> Diagnostics
Current Topics in Medicinal Chemistry The Potential Therapeutic Role of the HMGB1-TLR Pathway in Epilepsy
Current Drug Targets Signal Transduction in HIV Protein-Treated Astrocytes
Current Signal Transduction Therapy Anti-Toxoplasma Activity of Natural Products: A Review
Recent Patents on Anti-Infective Drug Discovery Current Immune Therapies of Autoimmune Disease of the Nervous System with Special Emphasis to Multiple Sclerosis
Current Pharmaceutical Design Meet Our Editorial Board Member
Reviews on Recent Clinical Trials Plant and Animal Steroids a New Hope to Search for Antiviral Agents
Current Medicinal Chemistry Bioactive N-Phenylimidazole Derivatives
Current Chemical Biology PET Imaging of the Peripheral Benzodiazepine Receptor: Monitoring Disease Progression and Therapy Response in Neurodegenerative Disorders
Current Pharmaceutical Design Patent Selections
Recent Patents on Anti-Cancer Drug Discovery The Role of Cytokines in T Help Responses to Viruses
Current Immunology Reviews (Discontinued) Herpes Simplex Virus Vectors for Gene Delivery to a Variety of Different Cell Types
Current Gene Therapy Target-oriented Mechanisms of Novel Herbal Therapeutics in the Chemotherapy of Gastrointestinal Cancer and Inflammation
Current Pharmaceutical Design Recombinant Rhabdoviruses as Potential Vaccines for HIV-1 and Other Diseases
Current HIV Research