Abstract
Tyrosine kinase receptors have been shown to play an important role in epithelial thyroid tumor growth and angiogenesis. Thyroid cancers commonly present oncogene mutations involved in MAPK kinase pathway like BRAF and RET; they are also frequently dependent on VEGF stimuli. Preliminary clinical experiences suggest a promising role of sunitinib (a tyrosine kinase inhibitor) for the treatment of advanced thyroid cancers. This review deals with the available data on the effect of sunitinib in the treatment of metastatic, radioiodine refractory thyroid cancers. We also report our experience with the off-label use of sunitinib in such patients.
Keywords: Thyroid cancer, sunitinib, tyrosin-kinase inhibitor, metastatic disease, Tyrosine kinase receptors, epithelial thyroid tumor, angiogenesis, oncogene mutations, MAPK kinase, BRAF, RET, VEGF stimuli
Mini-Reviews in Medicinal Chemistry
Title: The Emerging Role of Sunitinib in the Treatment of Advanced Epithelial Thyroid Cancer: Our Experience and Review of Literature
Volume: 11 Issue: 9
Author(s): G. Pasqualetti, S. Ricci, A. Dardano, M. Ferdeghini, M. Del Tacca and F. Monzani
Affiliation:
Keywords: Thyroid cancer, sunitinib, tyrosin-kinase inhibitor, metastatic disease, Tyrosine kinase receptors, epithelial thyroid tumor, angiogenesis, oncogene mutations, MAPK kinase, BRAF, RET, VEGF stimuli
Abstract: Tyrosine kinase receptors have been shown to play an important role in epithelial thyroid tumor growth and angiogenesis. Thyroid cancers commonly present oncogene mutations involved in MAPK kinase pathway like BRAF and RET; they are also frequently dependent on VEGF stimuli. Preliminary clinical experiences suggest a promising role of sunitinib (a tyrosine kinase inhibitor) for the treatment of advanced thyroid cancers. This review deals with the available data on the effect of sunitinib in the treatment of metastatic, radioiodine refractory thyroid cancers. We also report our experience with the off-label use of sunitinib in such patients.
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Pasqualetti G., Ricci S., Dardano A., Ferdeghini M., Del Tacca M. and Monzani F., The Emerging Role of Sunitinib in the Treatment of Advanced Epithelial Thyroid Cancer: Our Experience and Review of Literature, Mini-Reviews in Medicinal Chemistry 2011; 11 (9) . https://dx.doi.org/10.2174/138955711796355249
DOI https://dx.doi.org/10.2174/138955711796355249 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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