Abstract
The management of community-acquired pneumonia remains mainly driven by empiric antibiotic therapy because existing microbiological techniques are relatively insensitive and rarely deliver an answer within a useful time frame. Advances in the molecular detection of Streptococcus pneumoniae in whole blood have been published that suggest that a new era of diagnostics may be ready for routine clinical practice. As well as improved sensitivity over existing culture techniques and a very high specificity, the new assays quantitate the amount of bacteremia which appears to be an extremely useful prognostic marker. Here we review the recent studies and their implications in the setting of pneumococcoal pneumonia.
Keywords: Pneumococcus, PCR, quantitative, bacterial load, Molecular Diagnosis, community-acquired pneumonia, antibiotic therapy, blood, culture techniques, high specificity, alpha-hemolytic, respiratory tract, real-time PCR, DNA
Current Respiratory Medicine Reviews
Title: New Developments in Molecular Diagnosis of Bacteremic Pneumococcal Pneumonia
Volume: 7 Issue: 4
Author(s): Cordelia Kee, Ian Kay and Grant W. Waterer
Affiliation:
Keywords: Pneumococcus, PCR, quantitative, bacterial load, Molecular Diagnosis, community-acquired pneumonia, antibiotic therapy, blood, culture techniques, high specificity, alpha-hemolytic, respiratory tract, real-time PCR, DNA
Abstract: The management of community-acquired pneumonia remains mainly driven by empiric antibiotic therapy because existing microbiological techniques are relatively insensitive and rarely deliver an answer within a useful time frame. Advances in the molecular detection of Streptococcus pneumoniae in whole blood have been published that suggest that a new era of diagnostics may be ready for routine clinical practice. As well as improved sensitivity over existing culture techniques and a very high specificity, the new assays quantitate the amount of bacteremia which appears to be an extremely useful prognostic marker. Here we review the recent studies and their implications in the setting of pneumococcoal pneumonia.
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Kee Cordelia, Kay Ian and W. Waterer Grant, New Developments in Molecular Diagnosis of Bacteremic Pneumococcal Pneumonia, Current Respiratory Medicine Reviews 2011; 7 (4) . https://dx.doi.org/10.2174/157339811798281269
DOI https://dx.doi.org/10.2174/157339811798281269 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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