Generic placeholder image

Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

New Quinoline-Based Compounds for Analgesic and Anti-Inflammatory Evaluation

Author(s): Rizk Elsayed Khidre, Bakr Fathy Abdel-Wahab and Farid Abdel-Rehem Badria

Volume 8, Issue 7, 2011

Page: [640 - 648] Pages: 9

DOI: 10.2174/157018011796235194

Price: $65

Abstract

In this study, 2-chloroquinolin-3-carbaldehyde 1 was used as a synthon for the synthesis of some new quinoline; pyrane; indeno[1,2-b]pyrano[2,3-b]quinoline heterocycles. The anti-inflammatory and analgesic activities of the synthesized compounds were evaluated using carrageenan-induced paw edema and writhing assays. The obtained data indicated that the majority of the tested compounds exhibited both analgesic and anti-inflammatory activities, particularly compounds 2 and 6 showed a comparable effect to a well known analgesic and anti-inflammatory, diclofenac sodium.

Keywords: Quinoline, Pyranes, Knoevenagel reaction, Analgesic, Anti-inflammatory, X-ray analysis, heterocyclic compounds, 2-chloroquinolin-3-carbaldehydes, synthon, benzoylacetonitrile, NMR spectrum, hot plate test, X-Ray Crystallography, water ad libitum, pyrazole residues


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy