Abstract
In this manuscript, we review the latest advancement of microfluidics in molecular imaging probe development. Due to increasing needs for medical imaging, high demand for many types of molecular imaging probes will have to be met by exploiting novel chemistry/radiochemistry and engineering technologies to improve the production and development of suitable probes. The microfluidicbased probe synthesis is currently attracting a great deal of interest because of their potential to deliver many advantages over conventional systems. Numerous chemical reactions have been successfully performed in micro-reactors and the results convincingly demonstrate with great benefits to aid synthetic procedures, such as purer products, higher yields, shorter reaction times compared to the corresponding batch/macroscale reactions, and more benign reaction conditions. Several ‘proof-of-principle’ examples of molecular imaging probe syntheses using microfluidics, along with basics of device architecture and operation, and their potential limitations are discussed here.
Keywords: Microfluidics, molecular imaging, Probe Developments, Magnetic Resonance Imaging, Quantum Dots, Ultrasound Imaging, Microfluidic Devices, Imaging Modalities, Fluorescent Tags for Optical Imaging, Positron Emission Tomography
Current Organic Synthesis
Title: Molecular Imaging Probe Development Using Microfluidics
Volume: 8 Issue: 4
Author(s): Kan Liu, Ming-Wei Wang, Wei-Yu Lin, Duy Linh Phung, Mark D. Girgis, Anna M. Wu, James S. Tomlinson and Clifton K.-F. Shen
Affiliation:
Keywords: Microfluidics, molecular imaging, Probe Developments, Magnetic Resonance Imaging, Quantum Dots, Ultrasound Imaging, Microfluidic Devices, Imaging Modalities, Fluorescent Tags for Optical Imaging, Positron Emission Tomography
Abstract: In this manuscript, we review the latest advancement of microfluidics in molecular imaging probe development. Due to increasing needs for medical imaging, high demand for many types of molecular imaging probes will have to be met by exploiting novel chemistry/radiochemistry and engineering technologies to improve the production and development of suitable probes. The microfluidicbased probe synthesis is currently attracting a great deal of interest because of their potential to deliver many advantages over conventional systems. Numerous chemical reactions have been successfully performed in micro-reactors and the results convincingly demonstrate with great benefits to aid synthetic procedures, such as purer products, higher yields, shorter reaction times compared to the corresponding batch/macroscale reactions, and more benign reaction conditions. Several ‘proof-of-principle’ examples of molecular imaging probe syntheses using microfluidics, along with basics of device architecture and operation, and their potential limitations are discussed here.
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Cite this article as:
Liu Kan, Wang Ming-Wei, Lin Wei-Yu, Phung Duy Linh, D. Girgis Mark, M. Wu Anna, S. Tomlinson James and K.-F. Shen Clifton, Molecular Imaging Probe Development Using Microfluidics, Current Organic Synthesis 2011; 8 (4) . https://dx.doi.org/10.2174/157017911796117205
DOI https://dx.doi.org/10.2174/157017911796117205 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
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