Abstract
Hepatocyte growth factor/scatter factor (HGF/SF) acts as a mitogen, motogen and morphogen as well as an important angiogenic factor. In cancer cells, HGF/SF acts mainly as an inducer of cell migration and invasion with multiple motility signals mediated by the HGF receptor, c-MET. An important component in this signalling chain is the Rho/ROCK pathway, with resultant changes in cytoskeletal arrangement leading to cell motility/migration. This article outlines knowledge of HGF/SF in relation to cancer cell motility from previous reviews and focuses on more recent studies on the effect of HGF/SF in relation to RhoC GTPase and ROCK in breast cancer cells.
Keywords: Cancer cell motility, Hepatocyte growth factor/scatter factor, Rho, ROCK, GTPase, c-Met, metastasis, actin cytoskeleton, EMT, ribozyme, amoeboid cell motility, Y27632, lamellipodia, cancer cell invasion, RhoC, stress fibres, motility signals, Ras, doxycycline, mitogen, breat cancer, MDA-MB-231, MCF-7, Rho/rac pathway
Current Signal Transduction Therapy
Title: HGF and RhoGTPases in Cancer Cell Motility
Volume: 6 Issue: 2
Author(s): Jane Lane, Tracey A. Martin and Wen G. Jiang
Affiliation:
Keywords: Cancer cell motility, Hepatocyte growth factor/scatter factor, Rho, ROCK, GTPase, c-Met, metastasis, actin cytoskeleton, EMT, ribozyme, amoeboid cell motility, Y27632, lamellipodia, cancer cell invasion, RhoC, stress fibres, motility signals, Ras, doxycycline, mitogen, breat cancer, MDA-MB-231, MCF-7, Rho/rac pathway
Abstract: Hepatocyte growth factor/scatter factor (HGF/SF) acts as a mitogen, motogen and morphogen as well as an important angiogenic factor. In cancer cells, HGF/SF acts mainly as an inducer of cell migration and invasion with multiple motility signals mediated by the HGF receptor, c-MET. An important component in this signalling chain is the Rho/ROCK pathway, with resultant changes in cytoskeletal arrangement leading to cell motility/migration. This article outlines knowledge of HGF/SF in relation to cancer cell motility from previous reviews and focuses on more recent studies on the effect of HGF/SF in relation to RhoC GTPase and ROCK in breast cancer cells.
Export Options
About this article
Cite this article as:
Lane Jane, A. Martin Tracey and G. Jiang Wen, HGF and RhoGTPases in Cancer Cell Motility, Current Signal Transduction Therapy 2011; 6 (2) . https://dx.doi.org/10.2174/157436211795660052
DOI https://dx.doi.org/10.2174/157436211795660052 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Chronic Complications of Diabetes Mellitus: A Mini Review
Current Diabetes Reviews Isolation and Boactivities of Furfuran Type Lignan Compounds from Edible Plants
Recent Patents on Food, Nutrition & Agriculture Focal Adhesion Kinase: From In Vitro Studies to Functional Analyses In Vivo
Current Protein & Peptide Science Optimized Model for Cervical Cancer Detection Using Binary Cuckoo Search
Recent Patents on Computer Science Rapid Estrogen Signaling in Spermatogenesis
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Effect of Quantitative and Semi-quantitative Elastography Methods for the Management of Borderline Lesions on Ultrasonography
Current Medical Imaging Synthetic 2-Methoxyestradiol Derivatives: Structure-Activity Relationships
Current Medicinal Chemistry Stem Cells Therapies in Basic Science and Translational Medicine: Current Status and Treatment Monitoring Strategies
Current Pharmaceutical Biotechnology PET Radiopharmaceuticals for Personalized Medicine
Current Drug Targets Adhesion Molecules in Lung Cancer: Implications in the Pathogenesis and Management
Current Pharmaceutical Design Prognostic Value and Clinicopathological Differences of Bmi1 in Gastric Cancer: A Meta-analysis
Anti-Cancer Agents in Medicinal Chemistry Aim for the Readers! Bromodomains As New Targets Against Chagas’ Disease
Current Medicinal Chemistry Beneficial Action of Citrus Flavonoids on Multiple Cancer-Related Biological Pathways
Current Cancer Drug Targets Heterocyclic Analogues as Kinase Inhibitors: A Focus Review
Current Topics in Medicinal Chemistry Development and Application of Fourier-Transform Infrared Chemical Imaging of Tumour in Human Tissue
Current Medicinal Chemistry Marine Natural Products and Related Compounds as Anticancer Agents: an Overview of their Clinical Status
Anti-Cancer Agents in Medicinal Chemistry Circadian Rhythm in Cytokines Administration
Mini-Reviews in Medicinal Chemistry Brain Inflammation Following Intracerebral Hemorrhage
Current Neuropharmacology In Silico and Biochemical Analyses Identify Quinone Reductase 2 as a Target of Piceatannol
Current Medicinal Chemistry Oxidative Phosphorylation as a Target to Arrest Malignant Neoplasias
Current Medicinal Chemistry