Abstract
Hepatocyte growth factor (HGF) is a known angiogenic factor that has profound effects on vascular endothelial cells. In recent years, it has been reported that the factor also acts as a lymphagiogenic factor that induces lymphangenesis from lymphatic endothelial cells. The current article debates some of the recent evidence showing such an effect and also discusses the clinical studies that link to lymphatic related conditions, together with clinical implications.
Keywords: Hepatocyte growth factor, lymphangiogenesis, endothelial cells, VEGF, melanoma, cMET, lymph node metastases, prostate cancer, lymphatic invasion, metastasis, squamous cell carcinoma, lymphatic microvessel density, LYVE-1, Prox-1, VEGF-R3, breast cancer, HGF antagonist, in vivo tumour models, D2-40 antibody, MW 40K, ERK, akt, PECAM
Current Signal Transduction Therapy
Title: Hepatocyte Growth Factor is a Potential Lymphangiogenic Factor; Clinical Implications
Volume: 6 Issue: 2
Author(s): Wen G. Jiang and Andrew J. Sanders
Affiliation:
Keywords: Hepatocyte growth factor, lymphangiogenesis, endothelial cells, VEGF, melanoma, cMET, lymph node metastases, prostate cancer, lymphatic invasion, metastasis, squamous cell carcinoma, lymphatic microvessel density, LYVE-1, Prox-1, VEGF-R3, breast cancer, HGF antagonist, in vivo tumour models, D2-40 antibody, MW 40K, ERK, akt, PECAM
Abstract: Hepatocyte growth factor (HGF) is a known angiogenic factor that has profound effects on vascular endothelial cells. In recent years, it has been reported that the factor also acts as a lymphagiogenic factor that induces lymphangenesis from lymphatic endothelial cells. The current article debates some of the recent evidence showing such an effect and also discusses the clinical studies that link to lymphatic related conditions, together with clinical implications.
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Cite this article as:
G. Jiang Wen and J. Sanders Andrew, Hepatocyte Growth Factor is a Potential Lymphangiogenic Factor; Clinical Implications, Current Signal Transduction Therapy 2011; 6 (2) . https://dx.doi.org/10.2174/157436211795659900
DOI https://dx.doi.org/10.2174/157436211795659900 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
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