Abstract
Integrin α6β4 is the receptor for the laminin family of extracellular matrix proteins and is widely expressed in most epithelial tissues and Schwann cells. The expression of this integrin is up-regulated in most epithelial tumors, suggesting the role of α6β4 in their progression. The tumor microenvironment is also known to enhance the signaling competence of α6β4 through functional and physical interactions with other receptors. In this review, we discuss the biological mechanisms by which integrin α6β4 promotes carcinoma cell motility and invasion that leads to mammary tumor progression.
Keywords: metastasis, invasion, cell motility, carcinoma, Integrin α6β4
Current Protein & Peptide Science
Title: Role of α6β4 Integrin in Cell Motility, Invasion and Metastasis of Mammary Tumors
Volume: 12 Issue: 1
Author(s): Jun Chung, John L. Clifford, Young Hwa Soung and Hyea Jin Gil
Affiliation:
Keywords: metastasis, invasion, cell motility, carcinoma, Integrin α6β4
Abstract: Integrin α6β4 is the receptor for the laminin family of extracellular matrix proteins and is widely expressed in most epithelial tissues and Schwann cells. The expression of this integrin is up-regulated in most epithelial tumors, suggesting the role of α6β4 in their progression. The tumor microenvironment is also known to enhance the signaling competence of α6β4 through functional and physical interactions with other receptors. In this review, we discuss the biological mechanisms by which integrin α6β4 promotes carcinoma cell motility and invasion that leads to mammary tumor progression.
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Cite this article as:
Chung Jun, L. Clifford John, Hwa Soung Young and Jin Gil Hyea, Role of α6β4 Integrin in Cell Motility, Invasion and Metastasis of Mammary Tumors, Current Protein & Peptide Science 2011; 12 (1) . https://dx.doi.org/10.2174/138920311795659399
DOI https://dx.doi.org/10.2174/138920311795659399 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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