Abstract
In an investigation of 4-amino-3,4-dihydronaphthalen-1(2H)-ones as novel modulators of allergic and inflammatory phenomena, we have investigated a series of cyclic analogues. Tertiary amines of structural types 9, 10, 20 and 21 were synthesised and evaluated for mast cell stabilising activity. In vitro and in vivo studies showed that of these compounds, the cyclohexenylamino derivatives of tetralone and benzosuberone of series 20 and 21 exhibited interesting activity both in vitro and in vivo.
Keywords: Anti-allergic, benzosuberone, mast cell, tetralone, 4-amino-3,4-dihydronaphthalen-1(2H)-ones, cyclic analogues, Tertiary amines, cyclohexenylamino derivatives, Stabilising Activity, Anaphylaxis
Medicinal Chemistry
Title: Novel Mast Cell-Stabilising Amine Derivatives of 3,4-Dihydronaphthalen-1(2H)-one and 6,7,8,9-Tetrahydro-5H-benzo[7]annulen-5-one
Volume: 7 Issue: 3
Author(s): James W. Barlow, Tao Zhang, Orla Woods, Adam J. Byrne and John J. Walsh
Affiliation:
Keywords: Anti-allergic, benzosuberone, mast cell, tetralone, 4-amino-3,4-dihydronaphthalen-1(2H)-ones, cyclic analogues, Tertiary amines, cyclohexenylamino derivatives, Stabilising Activity, Anaphylaxis
Abstract: In an investigation of 4-amino-3,4-dihydronaphthalen-1(2H)-ones as novel modulators of allergic and inflammatory phenomena, we have investigated a series of cyclic analogues. Tertiary amines of structural types 9, 10, 20 and 21 were synthesised and evaluated for mast cell stabilising activity. In vitro and in vivo studies showed that of these compounds, the cyclohexenylamino derivatives of tetralone and benzosuberone of series 20 and 21 exhibited interesting activity both in vitro and in vivo.
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Cite this article as:
W. Barlow James, Zhang Tao, Woods Orla, J. Byrne Adam and J. Walsh John, Novel Mast Cell-Stabilising Amine Derivatives of 3,4-Dihydronaphthalen-1(2H)-one and 6,7,8,9-Tetrahydro-5H-benzo[7]annulen-5-one, Medicinal Chemistry 2011; 7 (3) . https://dx.doi.org/10.2174/157340611795564222
DOI https://dx.doi.org/10.2174/157340611795564222 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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