Solvent-Free Biginelli Reaction: A Green Method for the Synthesis of 3,4-Dihydropyrimidin-2-ones Catalyzed by Protic Acids in Large-Scale

Title: Solvent-Free Biginelli Reaction: A Green Method for the Synthesis of 3,4-Dihydropyrimidin-2-ones Catalyzed by Protic Acids in Large-Scale

Volume: 8 Issue: 4

Author(s): Yangyun Wang, Jipan Yu, Haohao Yang, Zhiwei Miao and Ruyu Chen

Affiliation:

Keywords: Biginelli reaction, 3,4-dihydropyrimidin-2-ones, solvent-free reaction, large-scale, mechanochemical reaction, toxicity, dicarbonyl, dihydropyrimidine, aldehyde, carboxylate

Abstract: An environmentally benign Biginelli reaction for the large-scale preparation of substituted 3,4- dihydropyrimidin-2(1H)-ones using protic acids as a catalyst has been achieved. These mechanochemical reactions proceed efficiently in the absence of organic solvent, with the assistance of infrared lamp irradiation.

Cite this article as:

Wang Yangyun, Yu Jipan, Yang Haohao, Miao Zhiwei and Chen Ruyu, Solvent-Free Biginelli Reaction: A Green Method for the Synthesis of 3,4-Dihydropyrimidin-2-ones Catalyzed by Protic Acids in Large-Scale, Letters in Organic Chemistry 2011; 8 (4) . https://dx.doi.org/10.2174/157017811795371386