Abstract
A new synthetic approach for the antiglaucoma agent, travoprost (1) has been developed in four steps from key intermediate (2). Key transformations include Horner – Wadsworth – Emmons reaction and separation of diastereomers to obtain (±) travoprost (1) and its analogs.
Keywords: Prostaglandins, antiglaucoma, (±) travoprost, Phosphonate, n-BuLi, dimethyl, methane, dimethoxyethane, alkylation
Letters in Organic Chemistry
Title: Synthesis of (±) Travoprost and its Analogs
Volume: 8 Issue: 4
Author(s): Harikrishna Mudduluru, Rama M. Hindupur, Pramod K. Dubey, Shankar Madhavaram, Lakshmikumar Tatini and Gottumukkala V. Subbaraju
Affiliation:
Keywords: Prostaglandins, antiglaucoma, (±) travoprost, Phosphonate, n-BuLi, dimethyl, methane, dimethoxyethane, alkylation
Abstract: A new synthetic approach for the antiglaucoma agent, travoprost (1) has been developed in four steps from key intermediate (2). Key transformations include Horner – Wadsworth – Emmons reaction and separation of diastereomers to obtain (±) travoprost (1) and its analogs.
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Cite this article as:
Mudduluru Harikrishna, M. Hindupur Rama, K. Dubey Pramod, Madhavaram Shankar, Tatini Lakshmikumar and V. Subbaraju Gottumukkala, Synthesis of (±) Travoprost and its Analogs, Letters in Organic Chemistry 2011; 8 (4) . https://dx.doi.org/10.2174/157017811795371485
DOI https://dx.doi.org/10.2174/157017811795371485 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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