Therapeutic Targets in Triple Negative Breast Cancer - Where are we now?

Yvonne      H.-F. Teng; Aye-Aye      Thike; Nan-Soon      Wong; Puay-Hoon      Tan

Abstract

Triple negative breast cancers, defined by lack of expression of estrogen receptor (ER), progesterone receptor (PR) and epidermal growth factor receptor 2 (Her2/EGFR2/ERBB2), are increasingly gaining attention for its intricate relationship with basal-like and BRCA1-linked breast carcinomas, and its lack of effective tailored therapies. Triple negative breast tumors usually account for 10-20% of all breast cancers in Asian populations, similarly in Caucasian populations (10-23%), but occur at much higher frequencies in individuals of African descent (20-47%). In addition, triple negative breast cancers are usually of high histological grade and are accompanied by aggressive clinical behavior with shorter time to recurrences and death, and preference for metastasis to the brain and lungs. In this report, we would like to review recent patents and the relationship between triple negative and basal-like breast cancers, as well as BRCA1-linked breast carcinomas. Specifically, potential treatment modalities and current innovations that are designed for the predictive and prognostic values of triple negative breast tumors will be discussed.

Keywords: Triple negative, basal-like, BRCA-1, treatment, targets, breast cancers, invasive ductal carcinoma, Chemotherapy, Receptor tyrosine kinase, tyrosine kinase inhibitors