Abstract
Development of array technologies started in the late 1980s, and today this technique has become a powerful tool for high throughput approaches in biology and chemistry. Progress was mainly driven by the human genome project and associated with the development of several new technologies, leading to the birth of additional “omic” topics such as proteomics, glycomics, or antibodyomics. In this review we focus strictly on peptide arrays applied to investigate protein-protein interactions, starting from single events up to complete interaction networks (interactomes). The specificities and interaction networks of protein interaction domains (PIDs) are our central theme. Picking practical examples from the literature, we review some general concepts about peptide arrays on planar supports for mapping protein-protein interactions.
Keywords: Peptide arrays, SPOT technology, protein interaction domains, peptide microarrays, human genome project, omic, protein-protein interactions, PIDs
Mini-Reviews in Organic Chemistry
Title: Exploring Protein-Protein Interactions with Synthetic Peptide Arrays
Volume: 8 Issue: 2
Author(s): Rudolf Volkmer and Victor Tapia
Affiliation:
Keywords: Peptide arrays, SPOT technology, protein interaction domains, peptide microarrays, human genome project, omic, protein-protein interactions, PIDs
Abstract: Development of array technologies started in the late 1980s, and today this technique has become a powerful tool for high throughput approaches in biology and chemistry. Progress was mainly driven by the human genome project and associated with the development of several new technologies, leading to the birth of additional “omic” topics such as proteomics, glycomics, or antibodyomics. In this review we focus strictly on peptide arrays applied to investigate protein-protein interactions, starting from single events up to complete interaction networks (interactomes). The specificities and interaction networks of protein interaction domains (PIDs) are our central theme. Picking practical examples from the literature, we review some general concepts about peptide arrays on planar supports for mapping protein-protein interactions.
Export Options
About this article
Cite this article as:
Volkmer Rudolf and Tapia Victor, Exploring Protein-Protein Interactions with Synthetic Peptide Arrays, Mini-Reviews in Organic Chemistry 2011; 8 (2) . https://dx.doi.org/10.2174/157019311795177718
DOI https://dx.doi.org/10.2174/157019311795177718 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
Call for Papers in Thematic Issues
Applications of Molecular Descriptors in Physicochemical Properties Research of Organic Compounds
Chemical graph theory is concerned with all aspects of the application of graph theory to various areas of chemistry, including organic, theoretical, mathematical, and computational chemistry, as well as in bioinformatics and computational biology. By the use of the term chemical it is emphasized that one is allowed in chemical ...read more
Exploring New Frontiers in Anti-inflammatory Treatment with Small Molecule Compounds
This thematic issue is dedicated to the latest advancements and research breakthroughs in the realm of anti-inflammatory pharmacotherapy. With inflammation playing a critical role in numerous chronic conditions such as cardiovascular diseases, diabetes, and autoimmune disorders, there is an urgent need for more targeted, effective, and safer anti-inflammatory treatments. This ...read more
Navigating the 2D Universe in Organic Chemistry
This special issue explores the transformative impact of two-dimensional (2D) materials on the realm of organic chemistry, unraveling new possibilities for synthesis, functionalization, and applications of organic compounds. Focused on the unique chemistry within this novel dimension, the issue highlights breakthroughs in the field of 2D organic chemistry. Contributions are ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Prion Protein Oligomerization
Current Alzheimer Research Estrogen Activates Classical and Alternative Mechanisms to Orchestrate Neuroprotection
Current Neurovascular Research 1,2,3-Triazine Scaffold as a Potent Biologically Active Moiety: A Mini Review
Mini-Reviews in Medicinal Chemistry Silybin and Silymarin - New and Emerging Applications in Medicine
Current Medicinal Chemistry Real-Time PCR: Revolutionizing Detection and Expression Analysis of Genes
Current Genomics MYC as Therapeutic Target for Embryonal Tumors: Potential and Challenges
Current Cancer Drug Targets The PI3K-AKt-mTOR Pathway and New Tools to Prevent Acquired Hormone Resistance in Breast Cancer
Current Pharmaceutical Biotechnology The MYCN Oncogene as a Specific and Selective Drug Target for Peripheral and Central Nervous System Tumors
Current Cancer Drug Targets The Potential of Microalgae for the Production of Bioactive Molecules of Pharmaceutical Interest
Current Pharmaceutical Biotechnology Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry
Medicinal Chemistry Current Status and Perspectives in Peptide Receptor Radiation Therapy
Current Pharmaceutical Design Vasopressin in Health and Disease with a Focus on Affective Disorders
Central Nervous System Agents in Medicinal Chemistry Phytochemicals in the Treatment of Alzheimer’s Disease: A Systematic Review
Current Drug Targets MicroRNAs in the Pathobiology of Multiple Myeloma
Current Cancer Drug Targets Mesenchymal Stem Cells: New Approaches for the Treatment of Neurological Diseases
Current Stem Cell Research & Therapy Molecular Mechanisms, Proteinopathies and Therapeutic Strategies in Neurodegenerative Disorders
Current Genomics Advances in Characterization of Neuroprotective Peptide, Humanin
Current Medicinal Chemistry Increased CRMP2 Phosphorylation is Observed in Alzheimers Disease; Does this Tell us Anything About Disease Development?
Current Alzheimer Research Shutting Down the Furnace: Preferential Killing of Cancer Cells with Mitochondrial-Targeting Molecules
Current Medicinal Chemistry Chromatin Structure and Epigenetics of Tumour Cells: A Review
Cardiovascular & Hematological Disorders-Drug Targets