Abstract
The reaction of a series of 1,2-diols with thionyl chloride led to bisnoradamantane sulfites in very good yields. The reaction has also been applied to related polycyclic scaffolds. The compounds have been tested for antiviral activity but none of them showed to be active. Several attempts to generate and trap SO from these polycyclic sulfites have been unsuccessful.
Keywords: Antiviral activity, bisnoradamantanes, polycyclic compounds, sulfites, sulfur monoxide, vesicular stomatitis virus, 1,2-diols, thionyl chloride, adamantane, ring-contracted analogs, memantine, rimantadine
Medicinal Chemistry
Title: Synthesis and Antiviral Evaluation of Bisnoradamantane Sulfites and Related Compounds
Volume: 7 Issue: 2
Author(s): Elena Valverde, Eva Torres, Salvador Guardiola, Lieve Naesens and Santiago Vazquez
Affiliation:
Keywords: Antiviral activity, bisnoradamantanes, polycyclic compounds, sulfites, sulfur monoxide, vesicular stomatitis virus, 1,2-diols, thionyl chloride, adamantane, ring-contracted analogs, memantine, rimantadine
Abstract: The reaction of a series of 1,2-diols with thionyl chloride led to bisnoradamantane sulfites in very good yields. The reaction has also been applied to related polycyclic scaffolds. The compounds have been tested for antiviral activity but none of them showed to be active. Several attempts to generate and trap SO from these polycyclic sulfites have been unsuccessful.
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Cite this article as:
Valverde Elena, Torres Eva, Guardiola Salvador, Naesens Lieve and Vazquez Santiago, Synthesis and Antiviral Evaluation of Bisnoradamantane Sulfites and Related Compounds, Medicinal Chemistry 2011; 7 (2) . https://dx.doi.org/10.2174/157340611794859299
DOI https://dx.doi.org/10.2174/157340611794859299 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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