Abstract
We report in this work the antimalarial activity of N-dodecyl-ethylenediamine (NDEDA). This compound was tested in vivo in a Plasmodium berghei murine model using the 4-day suppressive test in two separate experiments and displayed a very good inhibition of parasite multiplication.
Keywords: Antimalarial activity, Diamines, Malaria, Murine model, Plasmodium berghei, Polyamines, Lethal, Infectious Diseases, Protozoan Parasites, P. falciparum, P. vivax, P. malariae, P. Ovale, Trichomonas vaginalis, Trypanosoma cruzi
Letters in Drug Design & Discovery
Title: Antimalarial Activity of an N-Alkyl Diamine
Volume: 8 Issue: 4
Author(s): Nicolli B. de Souza, Carlos A. M. Rezende, Marcela S. Toledo, Davi C. Lagatta, Raphaela V. T. de Oliveira, Cristiane F. da Costa, Adilson D. da Silva, Marcio J. M. Alves, Sonia M. N. Cupolilo, Mauro V. de Almeida and Clarice Abramo
Affiliation:
Keywords: Antimalarial activity, Diamines, Malaria, Murine model, Plasmodium berghei, Polyamines, Lethal, Infectious Diseases, Protozoan Parasites, P. falciparum, P. vivax, P. malariae, P. Ovale, Trichomonas vaginalis, Trypanosoma cruzi
Abstract: We report in this work the antimalarial activity of N-dodecyl-ethylenediamine (NDEDA). This compound was tested in vivo in a Plasmodium berghei murine model using the 4-day suppressive test in two separate experiments and displayed a very good inhibition of parasite multiplication.
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Cite this article as:
B. de Souza Nicolli, A. M. Rezende Carlos, S. Toledo Marcela, C. Lagatta Davi, V. T. de Oliveira Raphaela, F. da Costa Cristiane, D. da Silva Adilson, J. M. Alves Marcio, M. N. Cupolilo Sonia, V. de Almeida Mauro and Abramo Clarice, Antimalarial Activity of an N-Alkyl Diamine, Letters in Drug Design & Discovery 2011; 8 (4) . https://dx.doi.org/10.2174/157018011794839439
DOI https://dx.doi.org/10.2174/157018011794839439 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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