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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Anxiolytic Activity of Some Novel 5-oxo-1, 4-oxazepine Derivatives

Author(s): Bothiana A. AbdelFattah, Maha M.A. Khalifa, Hend El-Sehrawi, Eman Fayed, Ashraf Bayoumi and Makarem Said

Volume 8, Issue 4, 2011

Page: [330 - 338] Pages: 9

DOI: 10.2174/157018011794839448

Price: $65

Abstract

A novel synthetic procedure for a series of 4-Aryl-3-phenyl-6,7,8,9-tetrahydro- benzothieno[3,2- f][1,4]oxazepin-5(4H)-one 8a-s derivatives had been described. Six compounds 8a,b,h,j,m,s were selected and submitted to pharmacological evaluation for anxiolytic activity in the open field test. All the test compounds except 8b significantly reduced the exploratory activity and the emotionality of the rats in the open-field. These inhibitory results are in agreement with the effect of reference standard chlorpromazine as a tranquillizer and anxiolytic in the same conditions.

Keywords: Synthesis, 5-Oxo-1, 4-Oxazepine derivatives, Open field test, Anxiolytic activity


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