Erbin, a Negative Regulator in Diverse Signal Pathways

Dan      Liu; Ming      Shi; Huijun      Duan; Caili      Han; Ning      Guo

Abstract

Erbin belongs to the LAP protein family. Originally, Erbin was described as a Her2-interacting protein. Recent studies demonstrated that Erbin could inhibit the Ras-mediated activation of the mitogen-activated protein kinase (MAPK), nuclear factor-κB (NF-κB) and transforming growth factor β (TGF-β) signaling pathways. It suggests that Erbin may function as a signaling molecule. The functions of Erbin in determining cell polarity and cell adhesion have been well described. This review mainly focuses on the recent findings in regulation of signaling pathways by Erbin.

Keywords: Erbin, MAPK, ERK, NF-κB, TGF-β, signal transduction, carbonyl termini, epithelial morphogensis, mutagenesis, velocardiofacial syndrome, down regulation