Abstract
There is a growing consensus that cellular immune responses are associated with the clinical outcome of hepatitis C virus infection (HCV). The development of Tetramer staining, ELISpot, flow cytometry and epitope mapping technologies makes it possible to enumerate, phenotype and assess the proliferation and function of HCV specific T cells; as well as map and predict T cell epitopes and track the evolution of T cell epitopes. Such information is essential for the development of effective therapeutic and prophylactic HCV vaccines. This article summarizes the technical advances relevant to HCV specific T cell responses.
Keywords: Hepatitis C Virus (HCV), T cell, proliferation, tetramer, ELISpot, epitope mapping, Tetramer staining, flow cytometry, prophylactic HCV vaccines, Flaviviridae virus, Cytotoxicity T LymphocyTE (CTL) Assays
Mini-Reviews in Medicinal Chemistry
Title: Advances in the Analysis of Hepatitis C Virus Specific T Cell Responses
Volume: 11 Issue: 2
Author(s): Xinjian Zhang, Jun Dou and Markus W. Germann
Affiliation:
Keywords: Hepatitis C Virus (HCV), T cell, proliferation, tetramer, ELISpot, epitope mapping, Tetramer staining, flow cytometry, prophylactic HCV vaccines, Flaviviridae virus, Cytotoxicity T LymphocyTE (CTL) Assays
Abstract: There is a growing consensus that cellular immune responses are associated with the clinical outcome of hepatitis C virus infection (HCV). The development of Tetramer staining, ELISpot, flow cytometry and epitope mapping technologies makes it possible to enumerate, phenotype and assess the proliferation and function of HCV specific T cells; as well as map and predict T cell epitopes and track the evolution of T cell epitopes. Such information is essential for the development of effective therapeutic and prophylactic HCV vaccines. This article summarizes the technical advances relevant to HCV specific T cell responses.
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Cite this article as:
Zhang Xinjian, Dou Jun and W. Germann Markus, Advances in the Analysis of Hepatitis C Virus Specific T Cell Responses, Mini-Reviews in Medicinal Chemistry 2011; 11 (2) . https://dx.doi.org/10.2174/138955711794519483
DOI https://dx.doi.org/10.2174/138955711794519483 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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