Novel Synthesis of Stagonolide-F, Putaminoxin and Aspinolide-A

Title: Novel Synthesis of Stagonolide-F, Putaminoxin and Aspinolide-A

Volume: 8 Issue: 2

Author(s): Ahmed Kamal, Papagari Venkat Reddy, Moku Balakrishna and Singaraboina Prabhakar

Affiliation:

Keywords: Decanolides, (S) and (R) malic acid, Horner-Wittig olefination, Steglich esterification, Brown's asymmetric allylboration, Ring closing metathesis (R.C.M.), microcarpalide, Stagonolide-F, putaminoxin, butyraldehyde

Abstract: Novel synthesis of putaminoxin, stagonolide-F and aspinolide-A have been achieved by utilizing (S) and (R)- malic acid. The key feature of the synthetic strategy includes Horner-Wittig olefination, double bond reduction and Steglich esterification. Olefinic acid for putaminoxin and stagonolide-F was prepared from (S)-malic acid whereas olefinic acid for aspinolide-A was prepared from (R)-malic acid and olefinic alcohols for putaminoxin, stagonolide-F and aspinolide-A were prepared by using Browns asymmetric allylboration.

Cite this article as:

Kamal Ahmed, Venkat Reddy Papagari, Balakrishna Moku and Prabhakar Singaraboina, Novel Synthesis of Stagonolide-F, Putaminoxin and Aspinolide-A, Letters in Organic Chemistry 2011; 8 (2) . https://dx.doi.org/10.2174/157017811794697502