Abstract
Despite recent advances in treatment of head and neck cancer, survival has not improved as expected. Bcl-2 family proteins play important role in regulating apoptosis. Recently, newer molecules have been developed for inhibition of Bcl-2 related proteins. We, herein aim to discuss the importance of Bcl-2 family proteins to the development of head and neck cancer and how the targeted-therapy for inhibition of Bcl-2 and related proteins, based on new drugs and recent patents, could improve the efficacy of the systemic therapy.
Keywords: Anticancer drugs, apoptosis, Bcl-2 family proteins, head and neck cancer, patents, targeted-therapy, squamous cell carcinoma, HNSCC, human papillomavirus (HPV) infection, radiochemotherapy, EGFR, FADD, tumorigenesis, Bcl-xL, Mcl-1, BH3-only, Bim, Puma, STAT3, fluoropyrimidines, VEGF, angiogenesis, TERT, Bortezomib, Human papillo-mavirus proteins, Azadirachta indica, gefitinib, Epigallocatechin-3 gallate, EGCG, Apogossypolone, Streptomyces, Chelidonium majus, obatoclax, BIE, BBF
Recent Patents on Anti-Cancer Drug Discovery
Title: Bcl-2 Targeted-Therapy for the Treatment of Head and Neck Squamous Cell Carcinoma
Volume: 6 Issue: 1
Author(s): Lucas V. dos Santos and Andre L. Carvalho
Affiliation:
Keywords: Anticancer drugs, apoptosis, Bcl-2 family proteins, head and neck cancer, patents, targeted-therapy, squamous cell carcinoma, HNSCC, human papillomavirus (HPV) infection, radiochemotherapy, EGFR, FADD, tumorigenesis, Bcl-xL, Mcl-1, BH3-only, Bim, Puma, STAT3, fluoropyrimidines, VEGF, angiogenesis, TERT, Bortezomib, Human papillo-mavirus proteins, Azadirachta indica, gefitinib, Epigallocatechin-3 gallate, EGCG, Apogossypolone, Streptomyces, Chelidonium majus, obatoclax, BIE, BBF
Abstract: Despite recent advances in treatment of head and neck cancer, survival has not improved as expected. Bcl-2 family proteins play important role in regulating apoptosis. Recently, newer molecules have been developed for inhibition of Bcl-2 related proteins. We, herein aim to discuss the importance of Bcl-2 family proteins to the development of head and neck cancer and how the targeted-therapy for inhibition of Bcl-2 and related proteins, based on new drugs and recent patents, could improve the efficacy of the systemic therapy.
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Cite this article as:
V. dos Santos Lucas and L. Carvalho Andre, Bcl-2 Targeted-Therapy for the Treatment of Head and Neck Squamous Cell Carcinoma, Recent Patents on Anti-Cancer Drug Discovery 2011; 6 (1) . https://dx.doi.org/10.2174/157489211793980042
DOI https://dx.doi.org/10.2174/157489211793980042 |
Print ISSN 1574-8928 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3970 |
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In recent years, traditional cancer treatments, such as surgery, chemotherapy, and radiation treatment, etc., may damage the pathological tissue and normal cells. The ideal tumor treatment should be noninvasive, eliminating the primary tumor, making the body produce systemic tumor-specific immunity, eliminating metastases, and having less /no side effects. Recent Patents ...read more
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