One-Pot Synthesis of Furans from Isoxazolines with Iron as Reducing Agent

Title: One-Pot Synthesis of Furans from Isoxazolines with Iron as Reducing Agent

Volume: 7 Issue: 8

Author(s): Dahong Jiang and Yuanwei Chen

Affiliation:

Keywords: Furan, isoxazoline, iron, reduction, optoelectronic, natural products, cyclocondensation, catalytic hydrogenation, 2-isoxazolines, hydroxy ketones, N, –, O bond cleavage, hydroxyimine, cyclodehydration, HCl, HOAc, reaction temperature, vinyl groups, acetic acid, solvents, NMR, CDCl3, MgSO4

Abstract: A highly efficient route to substituted furans from readily available 5-hydroxymethyl-substituted Δ2- isoxazolines is described. The transformation involves sequential reduction/hydrolysis/cyclocondensation in a one-pot reaction using iron as reducing agent under mild conditions.

Cite this article as:

Jiang Dahong and Chen Yuanwei, One-Pot Synthesis of Furans from Isoxazolines with Iron as Reducing Agent, Letters in Organic Chemistry 2010; 7 (8) . https://dx.doi.org/10.2174/157017810793811722